Rizzotto Giuseppe, Crosetti Erika, Lucioni Marco, Bertolin Andy, Monticone Valentina, Sprio Andrea Elio, Berta Giovanni Nicolao, Succo Giovanni
Otorhinolaryngology Department, Vittorio Veneto Hospital, Vittorio Veneto, Treviso, Italy.
Otorhinolaryngology Department, Martini Hospital, Turin, Italy.
Head Neck. 2015 Oct;37(10):1417-24. doi: 10.1002/hed.23773. Epub 2014 Jul 19.
Laryngeal cancer management should pursue function-sparing therapeutic options. Even though demolitive surgery provides better control of disease at intermediate to advanced stages when compared to chemoradiotherapy, it does not preserve laryngeal function. Supratracheal partial laryngectomy has been described as a function-sparing surgical technique for laryngeal cancer with subglottic extension.
In this retrospective study, we analyzed the clinical outcomes of 115 patients who underwent supratracheal partial laryngectomy.
At 5 years, overall survival (OS), disease-free survival (DFS), and locoregional control rates were 78.9%, 68.5%, and 69.6%, respectively; DFS and locoregional control prevalences were greatly affected by pT4a classification (49.0% and 51.4%, respectively); and laryngeal function preservation was maintained in 78.3% of patients despite being affected by pT4a classification (59.3%) and age ≥65 (64.6%).
For cases with glottic tumors and with subglottic extension, the choice of supratracheal partial laryngectomy versus chemoradiotherapy can be considered to be effective in terms of prognostic and functional results.
喉癌治疗应寻求保留功能的治疗方案。尽管与放化疗相比，根治性手术在中晚期能更好地控制疾病，但它无法保留喉功能。气管上部分喉切除术已被描述为一种针对伴有声门下扩展的喉癌的保留功能的手术技术。
在这项回顾性研究中，我们分析了115例行气管上部分喉切除术患者的临床结果。
5年时，总生存率（OS）、无病生存率（DFS）和局部区域控制率分别为78.9%、68.5%和69.6%；DFS和局部区域控制率受pT4a分类影响较大（分别为49.0%和51.4%）；尽管受pT4a分类（59.3%）和年龄≥65岁（64.6%）影响，但78.3%的患者仍保持喉功能保留。
对于声门肿瘤伴声门下扩展的病例，气管上部分喉切除术与放化疗相比，在预后和功能结果方面可被认为是有效的。
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