Winstock Adam R, Lawn Will, Deluca Paolo, Borschmann Rohan
South London and Maudsley NHS Trust, London, UK.
Addictions Clinical Academic Group, King's College London, Maudsley Hospital, London, UK.
Drug Alcohol Rev. 2016 Mar;35(2):212-7. doi: 10.1111/dar.12259. Epub 2015 Apr 13.
To assess the prevalence of use and subjective effect profile of methoxetamine among a group of polydrug users.
Cross-sectional, anonymous, online survey of UK-based polydrug users was conducted. Prevalence of lifetime, last year and last month use, sourcing of the drugs, motivations for use, and subjective effect and risk profile compared with that of ketamine were measured.
There were 7700 UK-based polydrug users, of whom 326 reported recent use of methoxetamine. Of the whole sample, 4.2% reported last 12 month use of methoxetamine compared with 24.5% for ketamine. The most common route of use was intranasal and the predominate effect described as psychedelic. Of the 15.5% of last year users of ketamine reporting last year use of methoxetamine, only 18.7% reported that they thought methoxetamine was less damaging to their kidneys or bladder than ketamine. Its broad effect profile, based on participants' first experience of use, was very similar to that of ketamine. Almost one-third of users reported that they did not intend to try the drug again.
Methoxetamine appears to have a broadly similar effect profile to that of ketamine. Only a minority of participants were motivated to use it because they believed it was less damaging to their kidneys or bladder than ketamine. The impact of the recent temporary banning order on availability and use of both methoxetamine and ketamine should be monitored carefully.
评估一组多药使用者中甲氧麻黄酮的使用流行率及其主观效应特征。
对英国的多药使用者开展了一项横断面、匿名在线调查。测量了终生、过去一年和过去一个月的使用流行率、药物来源、使用动机，以及与氯胺酮相比的主观效应和风险特征。
共有7700名英国多药使用者，其中326人报告近期使用过甲氧麻黄酮。在整个样本中，4.2%的人报告在过去12个月内使用过甲氧麻黄酮，而氯胺酮的这一比例为24.5%。最常见的使用途径是鼻内给药，主要效应被描述为致幻。在去年使用过氯胺酮且去年也使用过甲氧麻黄酮的使用者中，只有18.7%的人报告他们认为甲氧麻黄酮对肾脏或膀胱的损害比氯胺酮小。根据参与者的首次使用体验，其广泛的效应特征与氯胺酮非常相似。近三分之一的使用者报告他们不打算再次尝试该药物。
甲氧麻黄酮的效应特征似乎与氯胺酮大致相似。只有少数参与者因认为它对肾脏或膀胱的损害比氯胺酮小而有动机使用它。应仔细监测近期对甲氧麻黄酮和氯胺酮实施的临时禁令对其可得性和使用的影响。
