Sheng C-F, Liu B-Y, Zhang H-M, Zheng X
Department of Intensive Care Medicine, Taihe Hospital, Shiyan, China.
Department of Intensive Care Medicine, Taihe Hospital, Shiyan, China
Genet Mol Res. 2015 Mar 30;14(1):2702-6. doi: 10.4238/2015.March.30.30.
This report aims to deepen the understanding of the pathogenesis, diagnosis, clinical characteristics, and treatment of overwhelming postsplenectomy infection (OPSI). A patient treated at Taihe Hospital for tuberculous OPSI is described, and relevant literature is reviewed. Broad-spectrum antibiotics, suppression of the systemic inflammatory reaction, and anti-shock measures were the keys to the successful treatment of this condition. OPSI is a life-threatening condition and has a high mortality rate. Early diagnosis, use of anti-inflammatory glucocorticoids, and administration of high-dose gamma globulin and ulinastatin for the treatment of OPSI may improve outcomes.
本报告旨在加深对暴发性脾切除术后感染（OPSI）的发病机制、诊断、临床特征及治疗的理解。描述了1例在太和医院接受治疗的结核性OPSI患者，并对相关文献进行了回顾。广谱抗生素、抑制全身炎症反应及抗休克措施是成功治疗该病的关键。OPSI是一种危及生命的疾病，死亡率很高。早期诊断、使用抗炎糖皮质激素以及给予大剂量丙种球蛋白和乌司他丁治疗OPSI可能改善预后。
