Correale Jorge, Farez Mauricio F
Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea, FLENI, Argentina.
Department of Neurology, Institute for Neurological Research Dr. Raúl Carrea, FLENI, Argentina.
J Neuroimmunol. 2015 Apr 15;281:23-34. doi: 10.1016/j.jneuroim.2015.03.006. Epub 2015 Mar 6.
Smoking worsens multiple sclerosis (MS) prognosis. Our study provides evidence that indoleamine 2,3-dioxygenase activity is reduced in MS patients who smoke, leading to increased production of IL-6 and IL-13. Additionally, both degree of expression and renin-angiotensin system activity levels were increased in MS patients who smoked, inducing increase in IL-17 and IL-22-producing cell numbers as well as significantly greater production of CCL2, CCL3 and CXCL10 chemokines by monocytes. Finally, both pathways contributed to a significant decrease in the number of CD4+CD25+FoxP3+ regulatory T cells in MS patients who smoked. Both pathways could be responsible for the association between smoking and MS risk.
吸烟会使多发性硬化症（MS）的预后恶化。我们的研究表明，吸烟的MS患者中吲哚胺2,3-双加氧酶活性降低，导致白细胞介素-6（IL-6）和白细胞介素-13（IL-13）生成增加。此外，吸烟的MS患者中表达程度和肾素-血管紧张素系统活性水平均升高，导致产生IL-17和IL-22的细胞数量增加，以及单核细胞产生CCL2、CCL3和CXCL10趋化因子的量显著增多。最后，这两条途径都导致吸烟的MS患者中CD4+CD25+FoxP3+调节性T细胞数量显著减少。这两条途径都可能是吸烟与MS风险之间关联的原因。
