Li Haiyan, Dai Yongqiang, Wu Ai-Min, Sun Xiaobo, Lin Yinyao, Lv Kefeng, Lu Zhengqi
Department of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
Laboratory of Neurology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China.
J Neuroimmunol. 2015 Apr 15;281:38-43. doi: 10.1016/j.jneuroim.2015.02.014. Epub 2015 Mar 5.
To determine the differences of thyroid diseases and ATAbs in multiple sclerosis (MS) and NMOSDs, and to assess the independent impact factors of longitudinally extensive transverse myelitis (LETM) in NMOSDs.
Anti-thyroid peroxidase antibodies-positive (TPOAb(+)) and anti-thyroglobulin antibodies-positive (TGAb(+)) were most frequent in NMOSDs. LETM and lesions ≥6 vertebral segments were more frequent in TPOAb(+) NMOSDs than in TPOAb-negative (TPOAb(-)) NMOSDs. TGAb(+) NMOSDs with LETM were significantly more frequent than TGAb-negative (TGAb(-)) NMOSDs. TPOAb(+) and cerebrospinal fluid (CSF) abnormalities were independently associated with LETM.
Our findings demonstrate that ATAbs and thyroid diseases are significantly different in MS and NMOSD patients and CSs. TPOAb(+) and CSF abnormalities may be possible predictors of the severity of spinal cord lesions.
确定多发性硬化（MS）和视神经脊髓炎谱系疾病（NMOSDs）中甲状腺疾病及抗甲状腺自身抗体（ATAbs）的差异，并评估NMOSDs中长节段横贯性脊髓炎（LETM）的独立影响因素。
抗甲状腺过氧化物酶抗体阳性（TPOAb(+)）和抗甲状腺球蛋白抗体阳性（TGAb(+)）在NMOSDs中最为常见。TPOAb(+)的NMOSDs中LETM及病灶≥6个椎体节段的情况比TPOAb阴性（TPOAb(-)）的NMOSDs更常见。伴有LETM的TGAb(+)的NMOSDs明显比TGAb阴性（TGAb(-)）的NMOSDs更常见。TPOAb(+)和脑脊液（CSF）异常与LETM独立相关。
我们的研究结果表明，MS和NMOSD患者及临床孤立综合征（CSs）中ATAbs和甲状腺疾病存在显著差异。TPOAb(+)和CSF异常可能是脊髓病变严重程度的潜在预测指标。
