脓毒症对氯胺酮诱导的精神分裂症动物模型行为变化的影响。
Effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia.
作者信息
Comim Clarissa M, Silva Napoleão C, Patrício Janini J, Palmas Daphne, Mendonça Bruna P, Bittencourt Mariana O, Cassol Omar J, Barichello Tatiana, Zugno Alexandra I, Quevedo João, Dal-Pizzol Felipe
机构信息
Laboratory of Neuropathology, Postgraduate Program in Health Sciences, University of South Santa Catarina, Palhoça, SC, Brazil.
Laboratory of Neurosciences, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Criciúma, SC, Brazil.
出版信息
J Neuroimmunol. 2015 Apr 15;281:78-82. doi: 10.1016/j.jneuroim.2015.02.012. Epub 2015 Mar 3.
This study aimed to evaluate the effect of sepsis on behavioral changes on the ketamine-induced animal model of schizophrenia. Male Wistar rats underwent Cecal Ligation and Perporation (CLP) with "basic support" or were sham-operated. After 30 days, the animals were submitted to a model of schizophrenia by injection of Ketamine. The behavior tests were performed after 30 min of the injection of Ketamine or saline. Ketamine in doses of 15 and 25mg/kg increased locomotor activity, latency to first contact in the social interaction and stereotyped behavior. Some changes caused by sepsis may be associated with a predisposition to develop schizophrenia in the animal model.
本研究旨在评估脓毒症对氯胺酮诱导的精神分裂症动物模型行为变化的影响。雄性Wistar大鼠接受“基本支持”下的盲肠结扎和穿孔（CLP）手术或假手术。30天后，通过注射氯胺酮使动物建立精神分裂症模型。在注射氯胺酮或生理盐水30分钟后进行行为测试。15毫克/千克和25毫克/千克剂量的氯胺酮增加了运动活性、社交互动中首次接触的潜伏期和刻板行为。脓毒症引起的一些变化可能与动物模型中患精神分裂症的易感性有关。
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