纳米探针在无创性淋巴结示踪中的研究进展与展望。

Advances and perspectives in nanoprobes for noninvasive lymph node mapping.

机构信息

Shanghai East Hospital, The Institute for Biomedical Engineering & Nanoscience, Tongji University School of Medicine, Tongji University, Shanghai, 200092, PR China.

出版信息

Nanomedicine (Lond). 2015;10(6):1019-36. doi: 10.2217/nnm.14.201.

DOI:10.2217/nnm.14.201

PMID:25867863

Abstract

Sentinel lymph node (SLN) biopsy is now being well accepted as a practical approach to determine axillary lymph node status. For SLN biopsy, the mapping of SLN is an important procedure. However, blue dyes and radioactive colloids used for clinical SLN mapping are associated with a few issues such as adverse side effects and short retention time in SLN. In recent years, nanoscale probes for noninvasive SLN mapping have received attention due to their adaptable synthesis methods, adjustable optical properties and good biocompatibility. This review thoroughly summarizes the design of the nanoprobes and their properties in SLN mapping. The aim is to understand the status of nanomaterials for SLN mapping, challenging work and potential clinical translation in the future.

摘要

前哨淋巴结 (SLN) 活检目前已被广泛接受，是一种实用的方法，可用于确定腋窝淋巴结状态。对于 SLN 活检，SLN 的定位是一个重要的步骤。然而，用于临床 SLN 定位的蓝色染料和放射性胶体存在一些问题，如不良反应和在 SLN 中的短保留时间。近年来，由于纳米探针具有适应性强的合成方法、可调光学特性和良好的生物相容性，因此用于非侵入性 SLN 定位的纳米探针受到了关注。本文全面总结了纳米探针的设计及其在 SLN 定位中的性能。目的是了解用于 SLN 定位的纳米材料的现状、未来的挑战性工作和潜在的临床转化。