Mazzocchio R, Rossi A
Istituto di Scienze Neurologiche, Università di Siena, Italy.
Neurosci Lett. 1989 Nov 20;106(1-2):131-6. doi: 10.1016/0304-3940(89)90214-0.
Experiments involving the acute administration of a central cholinergic substance (L-acetylcarnitine) were performed on 6 healthy subjects to obtain additional evidence that the electrophysiological method developed by Bussel and Pierrot-Deseilligny in 1977 does actually assess recurrent inhibition in man. In all the subjects, the drug further decreased the amplitude of a test H reflex (H') following a conditioning H reflex (H1). The amount of this supplementary inhibition was found to be related to the size of H1 reflex. Experimental evidence is also presented that H' reflex supplementary depression is not contaminated by homonymous Ib effects. It is concluded that the method effectively tests the excitability of Renshaw cells in man.
对6名健康受试者进行了涉及急性给予中枢胆碱能物质（L-乙酰肉碱）的实验，以获取更多证据，证明1977年由布塞尔和皮埃罗 - 德西利尼开发的电生理方法确实可以评估人类的回返抑制。在所有受试者中，该药物进一步降低了在条件性H反射（H1）之后的测试H反射（H'）的幅度。发现这种额外抑制的量与H1反射的大小有关。还提供了实验证据，表明H'反射的额外抑制不受同名Ib效应的影响。得出的结论是，该方法有效地测试了人类中闰绍细胞的兴奋性。
