Sako Wataru, Murakami Nagahisa, Izumi Yuishin, Kaji Ryuji
Department of Clinical Neuroscience, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan.
Department of Clinical Neuroscience, Institute of Health Biosciences, Tokushima University Graduate School, Tokushima, Japan.
J Neurol Sci. 2015 May 15;352(1-2):84-7. doi: 10.1016/j.jns.2015.03.041. Epub 2015 Apr 7.
A reliable test that facilitates the accurate diagnosis of Parkinson's and disorders will help with both, clinical management and therapeutic research. In this context, neurofilament light chain (NFL) is candidate for a biomarker in cerebrospinal fluid (CSF). A comprehensive literature search yielded 4 eligible studies. We expressed between-group difference of NFL concentration in CSF as the standardized mean difference. Four studies involved 166 Parkinson's disease (PD), 116 multiple system atrophy (MSA) and 73 progressive supranuclear palsy (PSP) patients. Patients with MSA showed higher concentration of NFL concentration in CSF than those with PD (standardized mean difference=1.60, P<0.0001). These studies were homogeneous (P=0.17). NFL in CSF in PSP was significantly elevated relative to PD with homogeneous studies (standardized mean difference=2.04, P<0.0001; P=0.99). The present meta-analysis suggested that NFL concentration in CSF in MSA and PSP was significantly increased relative to PD, and that this could help us to separate PD from atypical parkinsonian syndromes.
一项有助于准确诊断帕金森病及相关疾病的可靠检测方法，将对临床管理和治疗研究均有帮助。在此背景下，神经丝轻链（NFL）是脑脊液（CSF）生物标志物的候选对象。全面的文献检索产生了4项符合条件的研究。我们将脑脊液中NFL浓度的组间差异表示为标准化均数差。4项研究涉及166例帕金森病（PD）、116例多系统萎缩（MSA）和73例进行性核上性麻痹（PSP）患者。MSA患者脑脊液中NFL浓度高于PD患者（标准化均数差=1.60，P<0.0001）。这些研究具有同质性（P=0.17）。在同质性研究中，PSP患者脑脊液中的NFL相对于PD显著升高（标准化均数差=2.04，P<0.0001；P=0.99）。本荟萃分析表明，MSA和PSP患者脑脊液中的NFL浓度相对于PD显著升高，这有助于我们将PD与非典型帕金森综合征区分开来。
