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一名患有过敏性紫癜的儿童继发水痘带状疱疹感染后的噬血细胞性淋巴组织细胞增生症。

Hemophagocytic lymphohistiocytosis secondary to Varicella zoster infection in a child with Henoch-Schönlein purpura.

作者信息

Gur Gokce, Cakar Nilgun, Uncu Nermin, Ayar Ganime, Basaran Ozge, Taktak Aysel, Koksoy Adem Yasin, Acar Banu, Caycı Fatma Semsa

机构信息

Pediatric Nephrology and Rheumatology, Ankara Child Health, Hematology, Oncology Education and Research Hospital, Ankara, Turkey.

出版信息

Pediatr Int. 2015 Apr;57(2):e37-8. doi: 10.1111/ped.12523.

Abstract

Hemophagocytic lymphohistiocytosis (HLH) is a fatal, hyper-inflammatory syndrome that is characterized by untimely activation of macrophages, and manifests as cytopenia, organ dysfunction, and coagulopathy. Secondary HLH can be associated with infection, drugs, malignancy, and transplantation, and is mostly triggered by infection. Herein, we report the case of a patient with Henoch-Schönlein purpura (HSP) who developed severe HLH secondary to Varicella zoster infection.

摘要

噬血细胞性淋巴组织细胞增生症(HLH)是一种致命的、高度炎症性综合征,其特征是巨噬细胞过早激活,并表现为血细胞减少、器官功能障碍和凝血病。继发性HLH可与感染、药物、恶性肿瘤和移植相关,且大多由感染引发。在此,我们报告一例患有过敏性紫癜(HSP)的患者,该患者因水痘带状疱疹感染继发严重HLH。

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