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From Bench to Bedside: Alpha-defensing--The Biggest Thing in Joint Replacement Infections Since Prophylactic Antibiotics?从实验室到临床：α-防御素——自预防性抗生素以来关节置换感染领域最重大的发现？
Clin Orthop Relat Res. 2015 Oct;473(10):3105-7. doi: 10.1007/s11999-015-4297-7. Epub 2015 Apr 14.
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Combined measurement of synovial fluid α-Defensin and C-reactive protein levels: highly accurate for diagnosing periprosthetic joint infection.联合检测滑液 α-防御素和 C 反应蛋白水平：诊断人工关节周围感染的高度准确方法。
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Detection of α-defensin in synovial fluids by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry as an innovative and cost-effective assay for improved definition of periprosthetic joint infections.基质辅助激光解吸电离飞行时间质谱法检测滑液中的α-防御素作为一种创新且具有成本效益的检测方法，可提高假体周围关节感染的定义能力。
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Synovial Fluid α-Defensin as a Biomarker for Peri-Prosthetic Joint Infection: A Systematic Review and Meta-Analysis.滑液α-防御素作为人工关节周围感染的生物标志物：一项系统评价和荟萃分析。
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[Not Available].[无可用内容]
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Systematic Review of Novel Synovial Fluid Markers and Polymerase Chain Reaction in the Diagnosis of Prosthetic Joint Infection.新型滑液标志物与聚合酶链反应在人工关节感染诊断中的系统评价
Am J Orthop (Belle Mead NJ). 2017 Jul/Aug;46(4):190-198.

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J Clin Microbiol. 2020 Apr 23;58(5). doi: 10.1128/JCM.01414-19.

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1
The alpha defensin-1 biomarker assay can be used to evaluate the potentially infected total joint arthroplasty.α-防御素-1生物标志物检测可用于评估潜在感染的全关节置换术。
Clin Orthop Relat Res. 2014 Dec;472(12):4006-9. doi: 10.1007/s11999-014-3900-7. Epub 2014 Sep 26.
2
Combined measurement of synovial fluid α-Defensin and C-reactive protein levels: highly accurate for diagnosing periprosthetic joint infection.联合检测滑液 α-防御素和 C 反应蛋白水平：诊断人工关节周围感染的高度准确方法。
J Bone Joint Surg Am. 2014 Sep 3;96(17):1439-45. doi: 10.2106/JBJS.M.01316.
3
Molecular techniques for diagnosing prosthetic joint infections.诊断人工关节感染的分子技术
J Antimicrob Chemother. 2014 Sep;69 Suppl 1:i21-4. doi: 10.1093/jac/dku249.
4
Diagnosing periprosthetic joint infection: has the era of the biomarker arrived?诊断人工关节周围感染：生物标志物时代已经到来了吗？
Clin Orthop Relat Res. 2014 Nov;472(11):3254-62. doi: 10.1007/s11999-014-3543-8.
5
Periprosthetic joint infection increases the risk of one-year mortality.人工关节周围感染会增加一年死亡率。
J Bone Joint Surg Am. 2013 Dec 18;95(24):2177-84. doi: 10.2106/JBJS.L.00789.
6
Diagnosis of periprosthetic joint infection.人工关节周围感染的诊断
J Arthroplasty. 2014 Feb;29(2 Suppl):77-83. doi: 10.1016/j.arth.2013.09.040. Epub 2013 Dec 15.
7
The 2013 Frank Stinchfield Award: Diagnosis of infection in the early postoperative period after total hip arthroplasty.2013 年弗兰克·斯廷奇菲尔德奖：全髋关节置换术后早期感染的诊断。
Clin Orthop Relat Res. 2014 Feb;472(2):424-9. doi: 10.1007/s11999-013-3089-1.
8
Correlation of aspiration results with periprosthetic sepsis in revision total hip arthroplasty.翻修全髋关节置换术后假体周围感染与吸引物结果的相关性。
J Arthroplasty. 2014 Feb;29(2):438-42. doi: 10.1016/j.arth.2013.06.020. Epub 2013 Jul 19.
9
New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society.人工关节周围感染的新定义：来自肌肉骨骼感染协会工作组。
Clin Orthop Relat Res. 2011 Nov;469(11):2992-4. doi: 10.1007/s11999-011-2102-9.
10
Synovial fluid biomarkers for periprosthetic infection.关节液生物标志物在假体周围感染中的应用。
Clin Orthop Relat Res. 2010 Aug;468(8):2017-23. doi: 10.1007/s11999-010-1298-4.

From Bench to Bedside: Alpha-defensing--The Biggest Thing in Joint Replacement Infections Since Prophylactic Antibiotics?

作者信息

Potter Benjamin K

机构信息

Department of Orthopaedics, Walter Reed National Military Medical Center, 8901 Wisconsin Ave, America Building (19), 2nd Floor - Ortho, Bethesda, MD, 20889, USA,

出版信息

Clin Orthop Relat Res. 2015 Oct;473(10):3105-7. doi: 10.1007/s11999-015-4297-7. Epub 2015 Apr 14.

DOI:10.1007/s11999-015-4297-7
PMID:25869063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4562918/
Abstract
摘要