Ortega-Ortega Marta, Oliva-Moreno Juan, Jiménez-Aguilera Juan de Dios, Romero-Aguilar Antonio, Espigado-Tocino Ildefonso
Applied Economic Department, University of Granada, Granada, Spain.
Economic Analysis Department and REDISSEC, University of Castilla La-Mancha, Castilla La-Mancha, Toledo, Spain.
Gac Sanit. 2015 May-Jun;29(3):178-83. doi: 10.1016/j.gaceta.2015.01.010. Epub 2015 Apr 11.
Stem cell transplantation has been used for many years to treat haematological malignancies that could not be cured by other treatments. Despite this medical breakthrough, mortality rates remain high. Our purpose was to evaluate labour productivity losses associated with premature mortality due to blood cancer in recipients of stem cell transplantations.
We collected primary data from the clinical histories of blood cancer patients who had undergone stem cell transplantation between 2006 and 2011 in two Spanish hospitals. We carried out a descriptive analysis and calculated the years of potential life lost and years of potential productive life lost. Labour productivity losses due to premature mortality were estimated using the Human Capital method. An alternative approach, the Friction Cost method, was used as part of the sensitivity analysis.
Our findings suggest that, in a population of 179 transplanted and deceased patients, males and people who die between the ages of 30 and 49 years generate higher labour productivity losses. The estimated loss amounts to over €31.4 million using the Human Capital method (€480,152 using the Friction Cost method), which means an average of €185,855 per death. The highest labour productivity losses are produced by leukaemia. However, lymphoma generates the highest loss per death.
Further efforts are needed to reduce premature mortality in blood cancer patients undergoing transplantations and reduce economic losses.
干细胞移植已被用于治疗多年来其他治疗方法无法治愈的血液系统恶性肿瘤。尽管有这一医学突破，但死亡率仍然很高。我们的目的是评估干细胞移植受者因血癌过早死亡而导致的劳动生产率损失。
我们从2006年至2011年在两家西班牙医院接受干细胞移植的血癌患者的临床病史中收集了原始数据。我们进行了描述性分析，并计算了潜在寿命损失年数和潜在生产寿命损失年数。使用人力资本法估计过早死亡导致的劳动生产率损失。作为敏感性分析的一部分，采用了另一种方法——摩擦成本法。
我们的研究结果表明，在179名移植后死亡的患者群体中，男性以及年龄在30至49岁之间死亡的人造成的劳动生产率损失更高。使用人力资本法估计的损失超过3140万欧元（使用摩擦成本法为480,152欧元），这意味着平均每例死亡损失185,855欧元。白血病造成的劳动生产率损失最高。然而，淋巴瘤导致的单例死亡损失最高。
需要进一步努力降低接受移植的血癌患者的过早死亡率，并减少经济损失。
