Moise K J, Deter R L, Kirshon B, Adam K, Patton D E, Carpenter R J
Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas.
Obstet Gynecol. 1989 Dec;74(6):905-8.
Intravenous pancuronium bromide was administered into the umbilical cord by funipuncture to effect temporary fetal paralysis. Neuromuscular blockade was achieved in 12 fetuses undergoing a total of 34 intrauterine procedures for the treatment of severe red-cell alloimmunization. The same initial dose of 0.2 mg/kg fetal weight estimated by ultrasound was used in all cases, but anemic fetuses did not resume movement for prolonged periods. A relationship among fetal hematocrit, adjusted dose, and duration of paralysis was described by the equation: Duration (hours) = 5.24 + 10.30 adjusted dose (mg/kg) - 0.16 hematocrit (%) (R2 = 0.49; P less than .001). Intravenous pancuronium was found to be a safe and effective method for cessation of fetal movement during intrauterine procedures.
通过脐血管穿刺向脐带内注射静脉用潘库溴铵，以实现胎儿暂时麻痹。对12例胎儿进行了总共34次宫内操作，用于治疗严重的红细胞同种免疫，均实现了神经肌肉阻滞。所有病例均采用超声估计的相同初始剂量，即胎儿体重0.2mg/kg，但贫血胎儿长时间未恢复活动。胎儿血细胞比容、调整剂量和麻痹持续时间之间的关系可用以下公式描述：持续时间（小时）=5.24 + 10.30调整剂量（mg/kg）- 0.16血细胞比容（%）（R2 = 0.49；P < 0.001）。发现静脉注射潘库溴铵是在宫内操作期间停止胎儿活动的一种安全有效的方法。
