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[免疫因素在葡萄膜性青光眼发病机制中的意义]

[The significance of immunologic factors in the pathogenesis of uveal glaucoma].

作者信息

Shchepetneva M A

出版信息

Oftalmol Zh. 1989(5):291-3.

PMID:2586974
Abstract

A study of the immunologic status in 60 patients with uveal glaucoma, of them 32 patients with chronic uveitis and 28 patients with uveopathies has revealed changes in the immunologic status in these two groups of patients: the reduction of the number of T-lymphocytes and T-suppressors, a tendency to reduction of the number of T-helpers and R-lymphocytes; sensibilization of leucocytes in these two groups of patients to antigens of the choroid, the retina, the iris and to antigens of the trabecular tissue: reduction of indices of migration with these antigens in experiment as compared with control investigations. A conclusion is made that the presence of the signs of immunodeficiency and signs of sensitization to autoantigens make it advisable to use immunocorrective and desensitizing preparations for treatment of patients with uveal glaucoma, especially in pre- and postoperative period.

摘要

对60例葡萄膜炎性青光眼患者(其中32例慢性葡萄膜炎患者和28例葡萄膜病患者)的免疫状态研究发现,这两组患者的免疫状态发生了变化:T淋巴细胞和T抑制细胞数量减少,T辅助细胞和R淋巴细胞数量有减少趋势;这两组患者的白细胞对脉络膜、视网膜、虹膜抗原以及小梁组织抗原敏感:与对照研究相比,实验中这些抗原的迁移指数降低。得出结论,免疫缺陷迹象和对自身抗原的敏感迹象的存在使得使用免疫纠正和脱敏制剂治疗葡萄膜炎性青光眼患者是可取的,尤其是在术前和术后阶段。

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