Incebiyik Adnan, Vural Mehmet, Camuzcuoglu Hakan, Taskin Abdullah, Camuzcuoglu Aysun, Hilali Nese Gul, Aksoy Nurten
Faculty of Medicine, Department of Gynecology and Obstetrics, Harran University, Yenisehir Campus, 63300, Sanliurfa, Turkey.
Faculty of Medicine, Department of Gynecology and Obstetrics, Marmara University, Istanbul, Turkey.
Wien Klin Wochenschr. 2016 Dec;128(Suppl 8):566-571. doi: 10.1007/s00508-015-0735-5. Epub 2015 Apr 14.
The objective of this study is to evaluate the prognostic value of M30 and M65 levels as markers of apoptotic activity and maternal serum oxidative stress in patients with complete hydatidiform mole (CHM).
In total, 68 pregnant women were included in the study. The study group included 34 pregnant with CHM, while 34 healthy pregnant were employed as a control group. Venous blood samples were drawn to assess the maternal serum oxidative stress and M30-M65 levels. In addition, a second blood sample was drawn from patients with CHM on day 8 after dilatation evacuation.
Maternal serum oxidative stress and M30-M65 levels were found to be significantly higher in patients with CHM as compared with the control group. It was found that serum β-subunit of human chorionic gonadotropin (β-hCG) level had a significant positive correlation with M30-M65 levels in patients with CHM. In addition, serum M65 level was found to be as effective as β-hCG in the identification of the patients with CHM.
Our results indicated that oxidative stress and apoptosis may play significant roles in CHM development. In addition, it seems that serum M30-M65 levels can presumably be an ancillary laboratory test to β-hCG in the diagnosis and follow-up of the patients with CHM.
本研究旨在评估M30和M65水平作为完全性葡萄胎（CHM）患者凋亡活性和母体血清氧化应激标志物的预后价值。
本研究共纳入68名孕妇。研究组包括34例CHM孕妇，34例健康孕妇作为对照组。采集静脉血样本以评估母体血清氧化应激及M30 - M65水平。此外，对CHM患者在刮宫术后第8天采集第二份血样。
发现CHM患者的母体血清氧化应激及M30 - M65水平显著高于对照组。发现CHM患者血清人绒毛膜促性腺激素β亚基（β - hCG）水平与M30 - M65水平呈显著正相关。此外，发现血清M65水平在识别CHM患者方面与β - hCG同样有效。
我们的结果表明氧化应激和凋亡可能在CHM的发生发展中起重要作用。此外，血清M30 - M65水平似乎可能成为CHM患者诊断和随访中β - hCG的辅助实验室检测指标。
