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法洛四联症修复术发展历程的个人见解。

Personal glimpses into the evolution of truncus arteriosus repair.

作者信息

Mavroudis Constantine, Jonas Richard A, Bove Edward L

机构信息

Johns Hopkins Children's Heart Surgery, Florida Hospital for Children, Orlando, FL, USA

Children's National Heart Institute, Washington DC, USA.

出版信息

World J Pediatr Congenit Heart Surg. 2015 Apr;6(2):226-38. doi: 10.1177/2150135115572375.

Abstract

Truncus arteriosus (common arterial trunk) is an uncommon but complex congenital heart anomaly. Until the early 1970s, typically, patients died between the age of a few weeks to six months. Congestive heart failure owing to large pulmonary blood flow and truncal valve regurgitation was the major cause of death until innovative surgical techniques were discovered. In 1963, Herbert Sloan at the University of Michigan completed the first repair using a nonvalved conduit with long-term survival (not reported until 1974). At the Mayo Clinic, Rastelli and McGoon studied and completed the first repair with a valved homograft in 1967. In 1976, Ebert used the 12-mm Hancock valved conduit in infants under six months of age (University of California, San Francisco). In Boston (mid-1980s), Jonas and Castañeda used aortic homografts, which greatly reduced bleeding as a postoperative complication. In the early 1990s, Bove (University of Michigan) reported outstanding results with an approach based on primary repair within the first few days of life for patients with truncus arteriosus. Improved prognosis for patients with truncus arteriosus resulted from these corrective operations by analyzing the natural history of this condition while applying innovative ideas, improved technology, and perioperative care.

摘要

动脉干(共同动脉干)是一种罕见但复杂的先天性心脏畸形。直到20世纪70年代初,通常情况下,患者会在几周至六个月大时死亡。在发现创新的手术技术之前,因大量肺血流和动脉干瓣膜反流导致的充血性心力衰竭是主要死因。1963年,密歇根大学的赫伯特·斯隆首次使用无瓣膜管道完成修复手术,患者获得长期生存(直到1974年才报道)。1967年,梅奥诊所的拉斯特利和麦贡研究并首次使用带瓣同种异体移植物完成修复手术。1976年,埃伯特在六个月以下婴儿中使用了12毫米的汉考克带瓣管道(加利福尼亚大学旧金山分校)。在波士顿(20世纪80年代中期),乔纳斯和卡斯塔涅达使用主动脉同种异体移植物,大大减少了术后出血并发症。20世纪90年代初,博夫(密歇根大学)报告了对动脉干患者在出生后几天内进行一期修复的方法取得了出色的效果。通过分析这种疾病的自然病史,同时应用创新理念、改进技术和围手术期护理,这些矫正手术改善了动脉干患者的预后。

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