Teles P, Barros S, Cardoso S, Facure A, da Rosa L A R, Santos M, Pereira P, Vaz P, Zankl M
CTN Pólo de Loures, Instituto Superior Técnico, Universidade de Lisboa, Estrada Nacional 10 (km 139,7), 2695-066 Bobadela, LRS, Portugal
Universidade Federal do Rio de Janeiro, Av. Pedro Calmon, 550, Rio de Janeiro 21941-901, Brazil.
Radiat Prot Dosimetry. 2015 Jul;165(1-4):482-7. doi: 10.1093/rpd/ncv055. Epub 2015 Apr 12.
In prostate brachytherapy treatments, there is an initial swelling of the prostate of the patient due to an oedema related to the insertion of the seeds. The variation of the prostate volume can lead to variations in the final prescribed dose in treatment planning procedures. As such, it is important to understand their influence for dose optimisation purposes. This work reports on a dosimetric study of the swelling of the prostate in prostate brachytherapy using Monte Carlo simulations. Dosimetric measurements performed on a physical anthropomorphic tissue-equivalent prostate phantom and thermoluminescent dosimeters (TLDs) were used to validate the MC model. Finally the MC model was also used to simulate prostate swelling in a real treatment planning procedure. The obtained results indicate that the parameters mentioned above represent a source of uncertainty in dose assessment in prostate brachytherapy, and can be detrimental to a correct dose evaluation in treatment plannings, and that these parameters can be accurately determined by means of MC simulations with a voxel phantom.
在前列腺近距离放射治疗中，由于与植入籽源相关的水肿，患者的前列腺会出现初始肿胀。前列腺体积的变化会导致治疗计划程序中最终处方剂量的变化。因此，为了剂量优化的目的，了解它们的影响很重要。这项工作报告了一项使用蒙特卡罗模拟对前列腺近距离放射治疗中前列腺肿胀进行的剂量学研究。在物理人体组织等效前列腺模型和热释光剂量计（TLD）上进行的剂量学测量用于验证蒙特卡罗模型。最后，蒙特卡罗模型还用于在实际治疗计划程序中模拟前列腺肿胀。所得结果表明，上述参数是前列腺近距离放射治疗剂量评估中不确定性的一个来源，可能对治疗计划中的正确剂量评估不利，并且这些参数可以通过体素模型的蒙特卡罗模拟准确确定。
