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羊膜在大泡性角膜病变姑息治疗中的应用。

Use of amniotic membrane in bullous keratopathy palliative care.

作者信息

Stefaniu G I, Chiotoroiu S M, Secureanu F A, Purcarea V L, Zemba M

机构信息

Clinical Ophthalmology Emergency Hospital Bucharest.

''Nicolae Malaxa'' Hospital, Bucharest.

出版信息

J Med Life. 2014;7 Spec No. 2(Spec Iss 2):88-91.

PMID:25870682
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4391353/
Abstract

BACKGROUND

Assessment of efficiency of amniotic membrane covering in the improvement of bullous keratopathy symptoms.

MATERIAL AND METHOD

The paper represents a clinical prospective study, which includes 42 patients diagnosed with bullous keratopathy and operated between January 2009 and November 2013 in the Department of Clinical Ophthalmology from "Dr. Carol Davila" Central Military Emergency Hospital. Follow up between 6 and 48 months, with an average of 22 months. Subject to research: corneal re-epithelisation, epithelial bullae, pain and photophobia relapse.

RESULTS

In 37 cases, the symptoms improved, in 8 cases the minimum symptoms persisted and in 29 cases the symptoms completely disappeared. In 5 cases, there were no significant improvements, symptoms reappeared briefly after membrane resorption.

CONCLUSIONS

Amniotic membrane covering represents an efficient palliative care means in oedematous keratopathy.

摘要

背景

评估羊膜覆盖在改善大泡性角膜病变症状方面的效果。

材料与方法

本文是一项临床前瞻性研究,纳入了2009年1月至2013年11月期间在“卡罗尔·达维拉博士”中央军事急救医院临床眼科接受手术的42例大泡性角膜病变患者。随访6至48个月,平均22个月。研究对象包括:角膜再上皮化、上皮大泡、疼痛和畏光复发情况。

结果

37例症状改善,8例仍有轻微症状,29例症状完全消失。5例无明显改善,羊膜吸收后症状短暂复发。

结论

羊膜覆盖是水肿性角膜病变有效的姑息治疗手段。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfb2/4391353/97aec1b453b4/JMedLife-07-88-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfb2/4391353/e26cd46fd3a0/JMedLife-07-88-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfb2/4391353/97aec1b453b4/JMedLife-07-88-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfb2/4391353/e26cd46fd3a0/JMedLife-07-88-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bfb2/4391353/97aec1b453b4/JMedLife-07-88-g002.jpg

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本文引用的文献

1
UV-riboflavin cross-linking of the cornea in bullous keratopathy: appraising the rationale.
Cornea. 2011 Jun;30(6):724-6; author reply 726. doi: 10.1097/ICO.0b013e3182014821.
2
Combined phototherapeutic keratectomy and amniotic membrane grafts for symptomatic bullous keratopathy.联合光治疗性角膜切除术和羊膜移植治疗症状性大疱性角膜病变。
Cornea. 2010 Oct;29(10):1207-8; author reply 1208-9. doi: 10.1097/ICO.0b013e3181d25ffe.
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Comparative evaluation of phototherapeutic keratectomy and amniotic membrane transplantation for management of symptomatic chronic bullous keratopathy.比较光动力角膜切削术与羊膜移植治疗症状性慢性大疱性角膜病变的效果。
Cornea. 2010 Sep;29(9):976-9. doi: 10.1097/ICO.0b013e3181ca369a.
4
[Palliative treatment in bullous keratopathy].[大疱性角膜病变的姑息治疗]
Oftalmologia. 2006;50(2):23-6.
5
Amniotic membrane transplantation for bullous keratopathy in eyes with poor visual potential.羊膜移植治疗视力预后差的眼大泡性角膜病变。
J Cataract Refract Surg. 2003 Feb;29(2):279-84. doi: 10.1016/s0886-3350(02)01525-0.
6
Amniotic membrane transplantation for symptomatic bullous keratopathy.羊膜移植治疗症状性大疱性角膜病变。
Arch Ophthalmol. 1999 Oct;117(10):1291-7. doi: 10.1001/archopht.117.10.1291.
7
Suppression of transforming growth factor-beta isoforms, TGF-beta receptor type II, and myofibroblast differentiation in cultured human corneal and limbal fibroblasts by amniotic membrane matrix.羊膜基质对培养的人角膜和角膜缘成纤维细胞中转化生长因子-β亚型、II型转化生长因子-β受体及肌成纤维细胞分化的抑制作用
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Pseudophakic bullous keratopathy. Relationship to preoperative corneal endothelial status.
Ophthalmology. 1984 Oct;91(10):1135-40.
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Chronic corneal edema.慢性角膜水肿
Am J Ophthalmol. 1973 Aug;76(2):201-7. doi: 10.1016/0002-9394(73)90160-8.