Zare-Shahabadi Ameneh, Masliah Eliezer, Johnson Gail V W, Rezaei Nima
Rev Neurosci. 2015;26(4):385-95. doi: 10.1515/revneuro-2014-0076.
Autophagy is a vesicle and lysosome-mediated degradative pathway that is essential for protein homeostasis and cell health. In particular, compared to nonneuronal cells, neurons are dependent on high basal autophagy for survival. There is emerging agreement that defects in autophagy are likely to contribute to the neurodegenerative processes in numerous diseases, including Alzheimer's disease (AD). Autophagy-lysosome defects occur early in the pathogenesis of AD and have been proposed to be a significant contributor to the disease process. Given the fact that autophagy deficits are likely major contributors to the etiology of AD, the focus of this review will be on recent studies that support a role for autophagy deficits in AD.
自噬是一种由囊泡和溶酶体介导的降解途径，对蛋白质稳态和细胞健康至关重要。特别是，与非神经元细胞相比，神经元依赖高水平的基础自噬来维持生存。越来越多的人一致认为，自噬缺陷可能导致包括阿尔茨海默病（AD）在内的多种疾病的神经退行性过程。自噬-溶酶体缺陷在AD发病机制的早期就会出现，并被认为是疾病进程的一个重要促成因素。鉴于自噬缺陷可能是AD病因的主要促成因素，本综述的重点将是支持自噬缺陷在AD中起作用的最新研究。
