Sannikova N E, Bykova V P, Grobov A O
Pediatriia. 1989(9):22-6.
As many as 100 children aged 3 months to 4 years with lymphaticohypoplastic diathesis (LHD) were examined for clinico-immunologic++ interrelations. The children suffering from manifest LHD demonstrated the reduction of the amount of circulating T lymphocytes and IgA, IgM and IgG subpopulations. At the same time the changes in local immunity correlating with enlargement of the thymus and lymphoid formations in the nasopharynx were identified. The immunity unbalance in LHD was supported by morphologic and immunologic studies of the tissue of the removed hypertrophied tonsils. The specification of the deranged mechanisms of immunity in LHD requires early diagnosis of the illness, screening of the methods for immunocorrection and closer follow-up of the sick children.
对多达100名年龄在3个月至4岁的患有淋巴发育不全素质（LHD）的儿童进行了临床免疫相互关系检查。患有明显LHD的儿童表现出循环T淋巴细胞以及IgA、IgM和IgG亚群数量减少。同时，发现局部免疫的变化与胸腺肿大及鼻咽部淋巴组织增生相关。对切除的肥大扁桃体组织进行的形态学和免疫学研究证实了LHD中免疫失衡的存在。明确LHD中免疫紊乱机制的具体情况需要对该病进行早期诊断、筛选免疫纠正方法并对患病儿童进行密切随访。
