Lavabre-Bertrand T, Donadio D, Breton A, Taib J, Charlier D, Assens C, Poncelet P, Murgue B, Vendrell J P, Emberger J M
Service des Maladies du Sang, Hôpital Lapeyronie, Montpellier, France.
Nouv Rev Fr Hematol (1978). 1989;31(5):345-8.
A case of chronic lymphocytic leukemia (CLL) treated with chlorambucil, followed by the development of an acute monoblastic leukemia, is described. Cytofluorometric quantitative immunophenotype was determined during the blastic phase. Whereas small lymphocytes displayed a CD19+; CD24+; CD37+; CD5+ phenotype, the blastic population exhibited, besides CD13, CD14 and CD15 positivity, which is usually noted in such a monoblastic leukemia, definite CD9, CD10, CD22, CD24, CD37, CD5 and CD4 staining. Such results argue against a complete independence between the two clones, although their similarity could not be demonstrated.
本文描述了一例慢性淋巴细胞白血病（CLL）患者，该患者接受苯丁酸氮芥治疗后，发展为急性单核细胞白血病。在原始细胞期进行了细胞荧光定量免疫表型分析。小淋巴细胞表现为CD19+；CD24+；CD37+；CD5+表型，而原始细胞群体除了通常在这种单核细胞白血病中可见的CD13、CD14和CD15阳性外，还表现出明确的CD9、CD10、CD22、CD24、CD37、CD5和CD4染色。这些结果表明两个克隆之间并非完全独立，尽管它们的相似性未能得到证实。
