Khawja Shumaila N, Mohammed Somala, Silberfein Eric J, Musher Benjamin L, Fisher William E, Van Buren George
From the *Michael E. DeBakey Department of Surgery, †The Elkins Pancreas Center, ‡Dan L. Duncan Cancer Center, and §Department of Medicine, Baylor College of Medicine, Houston, TX.
Pancreas. 2015 May;44(4):522-7. doi: 10.1097/MPA.0000000000000323.
Pancreatic cancer is the fourth leading cause of cancer-related deaths in the United States. The incidence of pancreatic cancer in African Americans is 50% to 90% higher than the incidence in other racial groups. African Americans also have the worst prognosis. This is an evidence-based review of pancreatic cancer in African Americans with particular emphasis on baseline characteristics, treatment, and survival.
We queried PubMed in search for articles describing racial disparities in pancreatic cancer. Two categories of terms were "anded" together: pancreatic cancer terms and race terms. The last search was performed on November 14, 2013.
We summarized the data on pancreatic cancer baseline characteristics, treatment, and survival for African Americans that we obtained from the following databases: (1) Surveillance, Epidemiology, and End Results, 1988-2008; (2) California Cancer Registry 1988-1998; (3) Cancer Survivor Program of Orange County/San Diego Imperial Organization for Cancer Control, 1988-1998; and (4) Harris County, 1998-2010.
Overall, pancreatic cancer survival of African Americans has not significantly improved over the past several decades despite advances in multimodality therapy; African Americans continue to face worse outcomes than whites. Although baseline characteristics, treatment, and biological factors offer some explanation, they do not completely explain the disparities in incidence and survival.
胰腺癌是美国癌症相关死亡的第四大主要原因。非裔美国人的胰腺癌发病率比其他种族群体高50%至90%。非裔美国人的预后也最差。这是一篇基于证据的关于非裔美国人胰腺癌的综述，特别强调基线特征、治疗和生存情况。
我们在PubMed上查询描述胰腺癌种族差异的文章。两类术语进行“与”运算：胰腺癌术语和种族术语。最后一次搜索于2013年11月14日进行。
我们总结了从以下数据库获得的非裔美国人胰腺癌基线特征、治疗和生存的数据：（1）监测、流行病学和最终结果，1988 - 2008年；（2）加利福尼亚癌症登记处，1988 - 1998年；（3）橙县/圣地亚哥帝国癌症控制组织癌症幸存者项目，1988 - 1998年；以及（4）哈里斯县，1998 - 2010年。
总体而言，尽管多模式治疗取得了进展，但在过去几十年里，非裔美国人的胰腺癌生存率并未显著提高；非裔美国人面临的结果仍比白人更差。虽然基线特征、治疗和生物学因素提供了一些解释，但它们并不能完全解释发病率和生存率的差异。
