Catli Gonul, Bostanci Ilknur, Ozmen Serap, Dibek Misirlioglu Emine, Duman Handan, Ertan Ulker
Department of Pediatrics, Dr. Sami Ulus Research and Training Hospital of Women's and Children's Health and Diseases, Ankara, Turkey.
Department of Pediatric Allergy and Immunology, Dr. Sami Ulus Research and Training Hospital of Women's and Children's Health and Diseases, Ankara, Turkey.
Pediatr Dermatol. 2015 Sep-Oct;32(5):684-9. doi: 10.1111/pde.12588. Epub 2015 Apr 15.
Atopy patch testing is a useful way to determine delayed-type hypersensitivity reactions to foods and aeroallergens. Although food additives have been accused of worsening atopic eczema symptoms, according to recent studies the role of food additives in atopic eczema remains unclear. The purpose of our study was to investigate food additive hypersensitivity in a group of children with atopic eczema by using standardized atopy patch testing and to determine the role of food additive hypersensitivity in atopic eczema.
Thirty-four children with atopic eczema and 33 healthy children were enrolled in the study. Children who consumed foods containing additives and did not use either antihistamines or local or systemic corticosteroids for at least 7 days prior to admission were enrolled in the study. All children were subjected to atopy patch testing and after 48 and 72 hours their skin reactions were evaluated by using the guidelines.
Positive atopy patch test results were significantly higher in the atopic eczema group. Forty-one percent of the atopic eczema group (n = 14) and 15.2% (n = 5) of the control group had positive atopy patch test results with food additives (p = 0.036) (estimated relative risk 1.68, case odds 0.7, control odds 0.17). Carmine hypersensitivity and the consumption of foods containing carmine, such as gumdrops, salami, and sausage, were significantly higher in the children with atopic eczema.
This is the first study investigating hypersensitivity to food additives in children with atopic eczema. Our results indicate that carmine may play a role in atopic eczema.
特应性皮炎斑贴试验是确定对食物和吸入性变应原迟发型超敏反应的一种有用方法。尽管食品添加剂被指责会加重特应性皮炎症状，但根据最近的研究，食品添加剂在特应性皮炎中的作用仍不明确。我们研究的目的是通过使用标准化的特应性皮炎斑贴试验来调查一组特应性皮炎儿童的食品添加剂超敏反应，并确定食品添加剂超敏反应在特应性皮炎中的作用。
34名特应性皮炎儿童和33名健康儿童参与了本研究。入选的儿童在入院前至少7天食用含添加剂的食物，且未使用抗组胺药或局部或全身性皮质类固醇。所有儿童均接受特应性皮炎斑贴试验，并在48小时和72小时后根据指南评估其皮肤反应。
特应性皮炎组的特应性皮炎斑贴试验阳性结果显著更高。特应性皮炎组中有41%（n = 14），对照组中有15.2%（n = 5）的儿童食品添加剂斑贴试验呈阳性（p = 0.036）（估计相对风险1.68，病例比值0.7，对照比值0.17）。特应性皮炎儿童中胭脂红超敏反应以及食用含胭脂红食物（如橡皮糖、意大利腊肠和香肠）的情况显著更高。
这是第一项调查特应性皮炎儿童对食品添加剂超敏反应的研究。我们的结果表明胭脂红可能在特应性皮炎中起作用。
