Centre for Evolution and Cancer, The Institute of Cancer Research, London, Brookes Lawley Building, 15 Cotswold Road, Sutton, Surrey SM2 5NG, UK.
Cancer Cell. 2015 Apr 13;27(4):433-4. doi: 10.1016/j.ccell.2015.03.016.
In a recent issue of Nature Genetics, Andersson and colleagues report that MLL fusion alone may be sufficient to spawn an aggressive leukemia in infants. Some other pediatric cancers may share a similar, single, "big-hit" origin, possibly reflecting a critical developmental window of stem cell vulnerability.
在最近一期的《自然遗传学》杂志上，安德松及其同事报告称，MLL 融合本身可能足以引发婴儿的侵袭性白血病。其他一些儿科癌症可能具有相似的单一“大打击”起源，这可能反映了干细胞脆弱性的关键发育窗口。
