Kennedy Nicholas J, Healy Paul J, Harrison Andrew A
Wellington Regional Rheumatology Unit, Hutt Valley DHB, Lower Hutt, New Zealand.
Int J Rheum Dis. 2016 Feb;19(2):205-10. doi: 10.1111/1756-185X.12578. Epub 2015 Apr 15.
To review inpatient management of acute gout in a New Zealand hospital.
A retrospective file review of all acute episodes of gout at Hutt Hospital, Wellington, New Zealand over a 1 year period.
In the course of a year, there were 90 admissions for, or complicated by, acute gout. In 31 cases, gout was the primary diagnosis. Median length of stay was 5 days and readmissions were common. The majority of patients (87%) were known to have gout before admission, yet only 50% of these patients were on uric acid lowering treatment. Serum urate was measured in only 60% of patients with a mean level of 0.471 mmol/L. Treatment for the acute attack was evenly split between monotherapy (49%) and polytherapy (49%). Treatment modalities used were: prednisone (61%), non-steroidal anti-inflammatories (40%), colchicine (40%), adrenocorticotrophic hormone (ACTH) (15%) and intrarticular steroids (7%). Patients were generally treated in a timely manner with few patients experiencing delays. Patients seen by the Rheumatology Department were more likely to receive polytherapy, be treated with intra-articular steroids or ACTH and to start allopurinol. The 'treat-to-target' approach to the management of elevated serum urate was mentioned in only 9% of cases.
There was considerable variability in the investigation and management of acute gout, with significant deviation from published protocols. The 'treat-to-target' approach to the management of elevated urate has not yet been widely adopted by the physicians in this New Zealand hospital.
回顾新西兰一家医院急性痛风的住院治疗情况。
对新西兰惠灵顿赫特医院1年内所有急性痛风发作病例进行回顾性病历审查。
在一年时间里,有90例因急性痛风入院或因急性痛风而出现并发症。其中31例痛风为主要诊断。中位住院时间为5天,再次入院情况较为常见。大多数患者(87%)在入院前已知患有痛风,但这些患者中只有50%正在接受降尿酸治疗。仅60%的患者检测了血清尿酸盐,平均水平为0.471 mmol/L。急性发作的治疗在单一疗法(49%)和联合疗法(49%)之间平均分配。使用的治疗方式有:泼尼松(61%)、非甾体抗炎药(40%)、秋水仙碱(40%)、促肾上腺皮质激素(ACTH)(15%)和关节内注射类固醇(7%)。患者通常得到及时治疗,很少有患者出现延误。风湿科诊治的患者更有可能接受联合疗法、接受关节内注射类固醇或ACTH治疗并开始使用别嘌醇。仅9%的病例提到了针对血清尿酸盐升高的“达标治疗”方法。
急性痛风的检查和治疗存在很大差异,与已发表的方案有显著偏差。新西兰这家医院的医生尚未广泛采用针对尿酸升高的“达标治疗”方法。