Kang Mingqiang, Sang Yonghua, Gu Haiyong, Zheng Liang, Wang Liming, Liu Chao, Shi Yijun, Shao Aizhong, Ding Guowen, Chen Suocheng, Tang Weifeng, Yin Jun
Department of Thoracic Surgery, Affiliated Union Hospital, Fujian Medical University, Fuzhou, 350001, Fujian Province, China,
Tumour Biol. 2015 Aug;36(8):6401-8. doi: 10.1007/s13277-015-3328-z. Epub 2015 Mar 31.
Worldwide, rates of esophageal cancer have been keeping highly in recent decades. Genetic variants in multiple cellular pathways might play an important role in altering risk of esophageal carcinoma. In this study, long noncoding RNAs (lncRNAs) functional single nucleotide polymorphisms (SNPs) were investigated in Chinese Han populations. We have genotyped the ANRIL rs2151280 T/C, POLR2E rs3787016 C/T, and HULC rs7763881 A/C SNPs in 380 esophageal squamous cell carcinoma (ESCC) cases and 380 cancer-free controls. POLR2E rs3787016 C/T was associated with a significantly decreased risk for ESCC (CT vs. CC: OR 0.62, 95 % CI 0.44-0.87, P = 0.005; adjusted OR 0.62, 95 % CI 0.44-0.87, P = 0.005). The other SNP, HULC rs7763881, also showed a suggestive association (AC vs. AA: OR 0.70, 95 % CI 0.50-0.98, P = 0.037; adjusted OR 0.69, 95 % CI 0.49-0.97, P = 0.031). ANRIL rs2151280 T/C SNP was not associated with risk of ESCC. In the future, larger studies with other ethnic populations, tissue-specific biological characterization, and detailed individual information should be undertaken to validate current findings.
在全球范围内，近几十年来食管癌发病率一直居高不下。多个细胞通路中的基因变异可能在改变食管癌风险方面发挥重要作用。在本研究中，对中国汉族人群中的长链非编码RNA（lncRNA）功能性单核苷酸多态性（SNP）进行了调查。我们对380例食管鳞状细胞癌（ESCC）患者和380例无癌对照进行了ANRIL rs2151280 T/C、POLR2E rs3787016 C/T和HULC rs7763881 A/C SNP基因分型。POLR2E rs3787016 C/T与ESCC风险显著降低相关（CT与CC相比：OR 0.62，95%CI 0.44 - 0.87，P = 0.005；校正OR 0.62，95%CI 0.44 - 0.87，P = 0.005）。另一个SNP，HULC rs7763881，也显示出提示性关联（AC与AA相比：OR 0.70，95%CI 0.50 - 0.98，P = 0.037；校正OR 0.69，95%CI 0.49 - 0.97，P = 0.031）。ANRIL rs2151280 T/C SNP与ESCC风险无关。未来，应开展涉及其他种族人群、组织特异性生物学特征和详细个体信息的更大规模研究，以验证当前研究结果。
