Liu Jinghua, Banskota Arjun H, Critchley Alan T, Hafting Jeff, Prithiviraj Balakrishnan
Department of Environmental Sciences, Faculty of Agriculture, Dalhousie University, P.O. Box 550, Truro, NS B2N 5E3, Canada.
Aquatic and Crop Resource Development, National Research Council Canada, 1411 Oxford Street, Halifax, NS B3H 3Z1, Canada.
Mar Drugs. 2015 Apr 14;13(4):2250-66. doi: 10.3390/md13042250.
Parkinson's disease (PD) is the second most common neurodegenerative disorder in the elderly people, currently with no cure. Its mechanisms are not well understood, thus studies targeting cause-directed therapy or prevention are needed. This study uses the transgenic Caenorhabditis elegans PD model. We demonstrated that dietary supplementation of the worms with an extract from the cultivated red seaweed Chondrus crispus decreased the accumulation of α-synulein and protected the worms from the neuronal toxin-, 6-OHDA, induced dopaminergic neurodegeneration. These effects were associated with a corrected slowness of movement. We also showed that the enhancement of oxidative stress tolerance and an up-regulation of the stress response genes, sod-3 and skn-1, may have served as the molecular mechanism for the C. crispus-extract-mediated protection against PD pathology. Altogether, apart from its potential as a functional food, the tested red seaweed, C. crispus, might find promising pharmaceutical applications for the development of potential novel anti-neurodegenerative drugs for humans.
帕金森病（PD）是老年人中第二常见的神经退行性疾病，目前无法治愈。其发病机制尚不完全清楚，因此需要开展针对病因导向治疗或预防的研究。本研究使用转基因秀丽隐杆线虫PD模型。我们证明，用养殖红海藻皱波角叉菜的提取物对线虫进行膳食补充，可减少α-突触核蛋白的积累，并保护线虫免受神经元毒素6-羟基多巴胺（6-OHDA）诱导的多巴胺能神经变性。这些作用与运动迟缓的改善有关。我们还表明，氧化应激耐受性的增强以及应激反应基因sod-3和skn-1的上调，可能是皱波角叉菜提取物介导的针对PD病理保护作用的分子机制。总之，除了作为功能性食品的潜力外，受试红海藻皱波角叉菜可能在开发潜在的新型人类抗神经退行性药物方面具有有前景的药用价值。
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