Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang 443000, Hubei Province, China; Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, Hubei Province, China.
Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang 443000, Hubei Province, China; Institute of Cardiovascular Diseases, China Three Gorges University, Yichang 443000, Hubei Province, China.
Atherosclerosis. 2015 Jun;240(2):355-66. doi: 10.1016/j.atherosclerosis.2014.12.048. Epub 2014 Dec 23.
Atherosclerosis is the most common pathological process that leads to cardiovascular diseases, a disease of large- and medium-sized arteries that is characterized by a formation of atherosclerotic plaques consisting of necrotic cores, calcified regions, accumulated modified lipids, smooth muscle cells (SMCs), endothelial cells, leukocytes, and foam cells. Recently, the question about how to suppress the occurrence of atherosclerosis and alleviate the progress of cardiovascular disease becomes the hot topic. Accumulating evidence suggests that histone deacetylases(HDACs) play crucial roles in arteriosclerosis. This review summarizes the effect of HDACs and HDAC inhibitors(HDACi) on the progress of atherosclerosis.
动脉粥样硬化是导致心血管疾病的最常见病理过程，是一种大中动脉疾病，其特征是形成由坏死核心、钙化区域、积累的改性脂质、平滑肌细胞（SMC）、内皮细胞、白细胞和泡沫细胞组成的动脉粥样硬化斑块。最近，关于如何抑制动脉粥样硬化的发生和减轻心血管疾病进展的问题成为热门话题。越来越多的证据表明组蛋白去乙酰化酶（HDACs）在动脉粥样硬化中发挥着重要作用。本综述总结了 HDACs 和 HDAC 抑制剂（HDACi）对动脉粥样硬化进展的影响。
