Schiefecker Alois Josef, Beer Ronny, Broessner Gregor, Kofler Mario, Schmutzhard Erich, Helbok Raimund
Division of Neurocritical Care, Department of Neurology, Medical University of Innsbruck , Innsbruck, Austria .
Ther Hypothermia Temp Manag. 2015 Sep;5(3):126-34. doi: 10.1089/ther.2014.0028. Epub 2015 Apr 15.
The impact of therapeutic hypothermia (TH) on long-term neurological outcome is still controversial. Data on the effects of TH on brain homeostasis are mostly derived from experimental research. Invasive multimodal neuromonitoring techniques may provide additional insight into pathophysiological changes associated with primary or secondary brain injury in humans. In this study we describe the principles of multimodal neuromonitoring and its potential in the clinical setting of TH. We call for more research using multimodal neuromonitoring techniques in patients undergoing TH to optimize cooling and rewarming strategies.
治疗性低温（TH）对长期神经功能结局的影响仍存在争议。关于TH对脑内环境稳定影响的数据大多来自实验研究。侵入性多模态神经监测技术可能会为人类原发性或继发性脑损伤相关的病理生理变化提供更多见解。在本研究中，我们描述了多模态神经监测的原理及其在TH临床环境中的潜力。我们呼吁在接受TH治疗的患者中开展更多使用多模态神经监测技术的研究，以优化降温及复温策略。
