长期使用丙咪嗪不会阻断可卡因引起的脑刺激奖赏增加。
Chronic imipramine does not block cocaine-induced increases in brain stimulation reward.
作者信息
Frank R A, Zubrycki E
机构信息
Department of Psychology, University of Cincinnati, OH 45221.
出版信息
Pharmacol Biochem Behav. 1989 Jul;33(3):725-7. doi: 10.1016/0091-3057(89)90416-4.
PMID:2587615
Abstract
Self-stimulating rats implanted with ventral tegmental area electrodes were tested with 15 mg/kg cocaine HCl before and after chronic imipramine treatment. Chronic imipramine had no influence on cocaine's ability to lower brain stimulation reward thresholds, suggesting that tricyclic antidepressant treatment does not block cocaine-induced euphoria.
摘要
给植入腹侧被盖区电极的自我刺激大鼠在慢性丙咪嗪治疗前后分别注射15毫克/千克盐酸可卡因进行测试。慢性丙咪嗪对可卡因降低脑刺激奖赏阈值的能力没有影响，这表明三环类抗抑郁药治疗不会阻断可卡因引起的欣快感。
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