He Cong, Xie Chuan, Lyu Nonghua
Wei Sheng Wu Xue Bao. 2014 Dec 4;54(12):1391-6.
Helicobacter pylori (H. pylori) is a gram-negative pathogen that widely colonizes in the human gastric mucosa, and is associated with various gastric diseases. Recently, much attention has been aroused on the relationship between H. pylori infection and autophagy. Accumulating evidence suggests that H. pylori can induce autophagy in gastric epithelial cells and professional phagocytes. Both the virulent factors of H. pylori and host autophagic proteins have been demonstrated to affect H. pylori-induced autophagy. Besides, the process of autophagy plays an important role in determining the intracellular fate of H. pylori. Here, we review the impact of H. pylori infection on autophagy of different cells.
幽门螺杆菌(H. pylori)是一种革兰氏阴性病原体,广泛定植于人类胃黏膜中,并与多种胃部疾病相关。最近,幽门螺杆菌感染与自噬之间的关系引起了广泛关注。越来越多的证据表明,幽门螺杆菌可诱导胃上皮细胞和专职吞噬细胞发生自噬。幽门螺杆菌的毒力因子和宿主自噬蛋白均已被证明会影响幽门螺杆菌诱导的自噬。此外,自噬过程在决定幽门螺杆菌的细胞内命运方面起着重要作用。在此,我们综述幽门螺杆菌感染对不同细胞自噬的影响。