Demiray Ebru, Bekmen Neslihan
Dokuz Eylül Universitesi Tip Fakültesi, Mikrobiyoloji ve Klinik Mikrobiyoloji Anabilim Dali, Izmir.
Mikrobiyol Bul. 2008 Jan;42(1):177-84.
Helicobacter pylori is a chronic infectious agent defined as the major pathogen causing gastritis, gastric and duodenal ulcer, gastric carcinoma and mucosa associated lenfoid tissue (MALT) lymphoma. H. pylori is the only microorganism known to get colonized in human stomach and inhabit in gastric mucosal cells. To achieve this, H. pylori must escape from both innate and adaptive immune responses. The host immune response is unable to eliminate the infection and this is generally associated with pathogenesis. The persistence of the induced H. pylori infection suggests that the response is not effective to eliminate the infection. In this review article, the correlation between H. pylori infection and innate immune response with emphasis on the avoidance of killing by phagocytosis, have been discussed.
幽门螺杆菌是一种慢性感染因子，被定义为引起胃炎、胃和十二指肠溃疡、胃癌以及黏膜相关淋巴组织（MALT）淋巴瘤的主要病原体。幽门螺杆菌是已知唯一能在人类胃部定植并栖息于胃黏膜细胞中的微生物。为实现这一点，幽门螺杆菌必须逃避先天免疫反应和适应性免疫反应。宿主的免疫反应无法消除感染，而这通常与发病机制相关。幽门螺杆菌感染的持续存在表明该免疫反应在消除感染方面无效。在这篇综述文章中，已讨论了幽门螺杆菌感染与先天免疫反应之间的相关性，重点是避免被吞噬作用杀灭。
