Fukui Yusuke, Yamashita Toru, Hishikawa Nozomi, Kurata Tomoko, Sato Kota, Omote Yoshio, Kono Syoichiro, Yunoki Taijun, Kawahara Yuko, Hatanaka Noriko, Tokuchi Ryo, Deguchi Kentaro, Abe Koji
Department of Neurology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan.
Intern Med. 2015;54(8):895-902. doi: 10.2169/internalmedicine.54.3931. Epub 2015 Apr 15.
The increasing population of elderly people in Japan has accelerated the demand for a simple screening test to detect cognitive and affective declines in mild cognitive impairment (MCI) and the early stage of dementia. Methods We compared the cognitive and affective functions, activities of daily living (ADLs) and the results of four computerized touch-panel screening tests in 41 MCI subjects, 124 patients with Alzheimer's disease (AD) and 75 age- and gender-matched normal controls.
All computerized touch-panel games were successfully used to discriminate the AD patients from the normal controls (** p<0.01). Although there were no differences in the findings of the conventional cognitive assessments, the results of the flipping cards game were significantly different (** p<0.01) between the normal controls (19.3 ± 9.5 sec) and MCI subjects (30.9 ± 18.4 sec). Three conventional affective assessments, the ADL score, Abe's behavioral and psychological symptoms of dementia (ABS) (** p<0.01) and the apathy scale (AS) (* p<0.05), could be used to discriminate the MCI subjects (ABS, 0.9 ± 1.5; AS, 12.8 ± 5.9) from the normal controls (ABS, 0.1 ± 0.4; AS, 8.9 ± 5.3).
In the present study, all four touch-panel screening tests could be employed to discriminate AD patients from normal controls, whereas only the flipping cards game was effective for distinguishing MCI subjects from normal controls. Therefore, this novel touch-panel screening test may be a more sensitive tool for detecting MCI subjects among elderly patients.
日本老年人口的不断增加，加速了对一种简单筛查测试的需求，以检测轻度认知障碍（MCI）和痴呆早期的认知及情感衰退。方法 我们比较了41名MCI受试者、124名阿尔茨海默病（AD）患者和75名年龄及性别匹配的正常对照者的认知和情感功能、日常生活活动能力（ADL）以及四项计算机化触摸屏筛查测试的结果。
所有计算机化触摸屏游戏均成功用于区分AD患者与正常对照者（**p<0.01）。虽然传统认知评估结果无差异，但正常对照者（19.3±9.5秒）和MCI受试者（30.9±18.4秒）之间的翻卡片游戏结果有显著差异（**p<0.01）。三项传统情感评估、ADL评分、阿部痴呆行为和心理症状量表（ABS）（**p<0.01）以及淡漠量表（AS）（*p<0.05）可用于区分MCI受试者（ABS，0.9±1.5；AS，12.8±5.9）与正常对照者（ABS，0.1±0.4；AS，8.9±5.3）。
在本研究中，所有四项触摸屏筛查测试均可用于区分AD患者与正常对照者，而只有翻卡片游戏对区分MCI受试者与正常对照者有效。因此，这种新型触摸屏筛查测试可能是检测老年患者中MCI受试者的更敏感工具。
