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不同孕周的中国新生儿出生体重曲线

[Chinese neonatal birth weight curve for different gestational age].

作者信息

Zhu Li, Zhang Rong, Zhang Shulian, Shi Wenjing, Yan Weili, Wang Xiaoli, Lyu Qin, Liu Ling, Zhou Qin, Qiu Quanfang, Li Xiaoying, He Haiying, Wang Jimei, Li Ruichun, Lu Jiarong, Yin Zhaoqing, Su Ping, Lin Xinzhu, Guo Fang, Zhang Hui, Li Shujun, Xin Hua, Han Yanqing, Wang Hongyun, Chen Dongmei, Li Zhankui, Wang Huiqin, Qiu Yinping, Liu Huayan, Yang Jie, Yang Xiaoli, Li Mingxia, Li Wenjing, Han Shuping, Cao Bei, Yi Bin, Zhang Yihui, Chen Chao

机构信息

Department of Neonatology, Children's Hospital of Fudan University, Shanghai 201102, China.

Email:

出版信息

Zhonghua Er Ke Za Zhi. 2015 Feb;53(2):97-103.

Abstract

OBJECTIVE

Since 1986, the reference of birth weight for gestational age has not been updated. The aim of this study was to set up Chinese neonatal network to investigate the current situation of birth weight in China, especially preterm birth weight, to develop the new reference for birth weight for gestational age and birth weight curve.

METHOD

A nationwide neonatology network was established in China. This survey was carried out in 63 hospitals of 23 provinces, municipalities and autonomous regions. We continuously collected the information of live births in participating hospitals during the study period of 2011-2014. Data describing birth weight and gestational age were collected prospectively. Newborn's birth weight was measured by electronic scale within 2 hours after birth when baby was undressed. The evaluation of gestational age was based on the combination of mother's last menstrual period, ultrasound in first trimester and gestational age estimation by gestational age scoring system.

STATISTICAL ANALYSIS

the growth curve was drawn by using LMSP method, which was conducted in GAMLSS 1.9-4 software package in R software 2.11.1.

RESULT

A total of 159 334 newborn infants were enrolled in this study. There were 84 447 male and 74 907 female. The mean birth weight was (3 232 ± 555) g, the mean birth weight of male newborn was (3 271 ± 576) g, the mean weight of female newborn was (3 188 ± 528) g. The test of the variables' distribution suggested that the distribution of gestational age and birth weight did not fit the normal distribution, the optimal distribution for them was BCT distribution. The Q-Q plot test and worm plot test suggested that this curve fitted the distribution optimally. The male and female neonatal birth weight curve was developed using the same method.

CONCLUSION

Using GAMLSS method to establish nationwide neonatal birth weight curve, and the first time to update the birth weight reference in recent 28 years.

摘要

目的

自1986年以来,胎龄别出生体重参考值一直未更新。本研究旨在建立中国新生儿网络,调查中国出生体重现状,尤其是早产出生体重情况,制定新的胎龄别出生体重参考值及出生体重曲线。

方法

在中国建立了全国范围的新生儿科网络。本调查在23个省、直辖市和自治区的63家医院开展。在2011年至2014年研究期间,持续收集参与医院活产儿的信息。前瞻性收集描述出生体重和胎龄的数据。新生儿出生体重在出生后2小时内婴儿裸体时用电子秤测量。胎龄评估基于母亲末次月经日期、孕早期超声检查以及胎龄评分系统进行胎龄估计三者相结合的方法。

统计分析

采用LMSP方法绘制生长曲线,在R软件2.11.1的GAMLSS 1.9 - 4软件包中进行。

结果

本研究共纳入159334例新生儿。其中男性84447例,女性74907例。平均出生体重为(3232±555)g,男性新生儿平均出生体重为(3271±576)g,女性新生儿平均体重为(3188±528)g。变量分布检验表明,胎龄和出生体重的分布不符合正态分布,其最佳分布为BCT分布。Q - Q图检验和蠕虫图检验表明该曲线与分布拟合最优。采用相同方法绘制了男性和女性新生儿出生体重曲线。

结论

采用GAMLSS方法建立了全国范围的新生儿出生体重曲线,且首次在近28年更新了出生体重参考值。

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