Xiong Minghui, Pan Ting, Zhang Zhanzhan, Zhong Yuanfeng, Chen Qian, Wan Yannan, Zhu Lin, Chen Li, Zhang Xuan
Department of Growth, Development and Mental Health of Children and Adolescence Center of Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Neurodevelopment and Cognitive Disorders, Chongqing, China.
Guizhou Branch of Shanghai Children's Medical Center Shanghai Jiaotong University School of Medicine, Guiyang, China.
Sci Rep. 2025 May 25;15(1):18265. doi: 10.1038/s41598-025-03360-6.
To compare the difference between appropriate for gestational age (AGA) and small for gestational age (SGA) of singleton and twin in terms of catch-up growth (CUG) and nutritional status in the first year after birth through a prospective cohort study. A total of 340 singleton and twin children were recruited. Dietary questionnaires were completed at enrollment and at 3 and 6 months of age. Anthropometric data were presented as Z scores. The Z score of weight, length and/or head circumference > - 2SD were used as criteria for CUG. The CUG rate of the twin AGA was the highest. Rapid CUG of twin SGA occurred within 3 months, and the CUG rate of weight was greater for twin SGA than for singleton SGA at 1 year old. The length CUG rate for twin SGA was the lowest within 3 months, 17.05% of the singleton SGA and 22.22% of the twin SGA did not reach CUG. The CUG was independent of feeding mode, and higher energy support did not improve CUG outcome. Twin AGA children have a better CUG rate, whereas CUG might take longer in SGA, especially for twin SGA. Higher energy support does not necessarily improve CUG outcomes.Trial registration number The study was registered in the Chinese Clinical Trial Registry with registration number ChiCTR2100053434 and was recorded in the medical research registry. Date of registration: Nov 21, 2021.
通过一项前瞻性队列研究，比较单胎和双胎适于胎龄儿（AGA）与小于胎龄儿（SGA）在出生后第一年的追赶生长（CUG）和营养状况的差异。共招募了340名单胎和双胎儿童。在入组时以及3个月和6个月龄时完成饮食问卷。人体测量数据以Z评分表示。体重、身长和/或头围的Z评分> -2SD被用作CUG的标准。双胎AGA的CUG率最高。双胎SGA在3个月内出现快速CUG，1岁时双胎SGA的体重CUG率高于单胎SGA。双胎SGA在3个月内的身长CUG率最低，17.05%的单胎SGA和22.22%的双胎SGA未达到CUG。CUG与喂养方式无关，更高的能量支持并未改善CUG结果。双胎AGA儿童的CUG率更好，而SGA的CUG可能需要更长时间，尤其是双胎SGA。更高的能量支持不一定能改善CUG结果。试验注册号 该研究已在中国临床试验注册中心注册，注册号为ChiCTR2100053434，并记录在医学研究注册库中。注册日期：2021年11月21日。
