Zhu Li, Geng Daoying, Ren Guang, Tang Weijun, Li Ke, Zhang Jun, Ye Jianding
Department of Radiology, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China.
Department of Radiology, Huashan Hospital, Fudan University, Shanghai 200040. Email:
Zhonghua Yi Xue Za Zhi. 2015 Jan 6;95(1):37-9.
To explore the correlation between minimal apparent diffusion coefficient (minADC) and expression of Ki-67 in glioma.
Findings from 78 patients with pathologically proven gliomas (grade II:n = 28, grade III: n = 21, grade IV: n = 29) were analyzed retrospectively. The minADC value of each tumor was determined on ADC maps. The Ki-67 labeling index (LI) of surgical specimen was measured. The results were analyzed statistically.
The mean value of minADC for gliomas of grade II ((1.23 ± 0.23)×10(-3) mm(2/s)) was higher than that of grade III ((0.92 ± 0.20)×10(-3) mm(2/s)) (P < 0.01) and than that of grade IV ((0.80 ± 0.16)×10(-3) mm(2)/s) (P < 0.01). But no significant difference existed between the mean value of minADC of grade III and that of grade IV (P = 0.069). There were significant negative correlations between minADC and different tumor grades (r = -0.678, P < 0.01). The mean value of Ki-67 LI showed significant differences between grade II (3.6% ± 2.3%), grade III (14.8% ± 7.3%) and grade IV (29.9% ± 13.1%) (P < 0.01). There were significant positive correlations between Ki-67 LI and different tumor grades (r = 0.835, P < 0.01). And a negative correlation existed between minADC and Ki-67 LI (r = -0.556, P < 0.01).
The value of minADC is useful for predicting glioma grade.
探讨脑胶质瘤最小表观扩散系数（minADC）与Ki-67表达之间的相关性。
回顾性分析78例经病理证实的脑胶质瘤患者（Ⅱ级：n = 28，Ⅲ级：n = 21，Ⅳ级：n = 29）的资料。在表观扩散系数（ADC）图上测定每个肿瘤的minADC值。测量手术标本的Ki-67标记指数（LI）。对结果进行统计学分析。
Ⅱ级脑胶质瘤的minADC平均值（(1.23 ± 0.23)×10(-3) mm(2/s)）高于Ⅲ级（(0.92 ± 0.20)×10(-3) mm(2/s)）（P < 0.01），也高于Ⅳ级（(0.80 ± 0.16)×10(-3) mm(2)/s）（P < 0.01）。但Ⅲ级和Ⅳ级的minADC平均值之间无显著差异（P = 0.069）。minADC与不同肿瘤分级之间存在显著负相关（r = -0.678，P < 0.01）。Ki-67 LI的平均值在Ⅱ级（3.6% ± 2.3%）、Ⅲ级（14.8% ± 7.3%）和Ⅳ级（29.9% ± 13.1%）之间存在显著差异（P < 0.01）。Ki-67 LI与不同肿瘤分级之间存在显著正相关（r = 0.835，P < 0.01）。并且minADC与Ki-67 LI之间存在负相关（r = -0.556，P < 0.01）。
minADC值有助于预测脑胶质瘤分级。
