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[孕期麻醉与疼痛管理]

[Anesthesia and pain management during pregnancy].

作者信息

Ninke T, Thoma-Jennerwein S, Blunk J, Annecke T

机构信息

Klinik für Anästhesiologie, Klinikum der Universität München (LMU), München, Deutschland.

出版信息

Anaesthesist. 2015 May;64(5):347-56. doi: 10.1007/s00101-015-0023-9.

Abstract

During the perioperative and postoperative care of pregnant women it is prudent to pay close attention to the changed physiology of these patients. The main principles of care are the preservation of maternal and fetal homeostasis as well as avoidance of any substances with toxic effects on the fetus. In order to provide pregnant patients with good quality care, all relevant disciplines should be involved as early as possible. Modern anesthetic drugs can be used as they seem to be without teratogenic effects. Adequate perioperative surveillance and assessment of the fetus is also important.The mainstay of pain management during pregnancy is the World Health Organization (WHO) pain ladder. It is of the utmost importance to use only substances without teratogenic or fetotoxic properties. Considering non-opioid drugs, the use of paracetamol is a viable option, whereas non-steroidal anti-inflammatory drugs (NSAID) should only be used with rigorous restrictions. Tramadol is a first-line drug when using opioids with low potency, whereas morphine can be used as an opioid with a higher potency after careful consideration of the risk-benefit ratio. If possible anticonvulsives should not be used as an adjunct in pain management during pregnancy. The use of thoroughly investigated antidepressants seems to be a better alternative. Apart from drug therapy it is important to use all available conservative pain treatment options.

摘要

在孕妇围手术期和术后护理过程中,谨慎密切关注这些患者生理机能的变化至关重要。护理的主要原则是维持母婴体内稳态,同时避免使用任何对胎儿有 toxic 作用的物质。为了给孕妇提供高质量护理,所有相关学科应尽早参与。现代麻醉药物可在看似无致畸作用的情况下使用。对胎儿进行充分的围手术期监测和评估也很重要。孕期疼痛管理的主要依据是世界卫生组织(WHO)疼痛阶梯。仅使用无致畸或胎儿毒性特性的物质至关重要。考虑到非阿片类药物,使用对乙酰氨基酚是一个可行的选择,而非甾体抗炎药(NSAID)仅应在严格限制下使用。使用低效力阿片类药物时,曲马多是一线药物,而在仔细权衡风险效益比后,吗啡可作为效力较高的阿片类药物使用。如果可能,孕期疼痛管理中不应将抗惊厥药用作辅助药物。使用经过充分研究的抗抑郁药似乎是更好的选择。除药物治疗外,使用所有可用的保守疼痛治疗选项也很重要。

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