Gulko G M, Djomina E A, Cernicenko V A
Radiobiol Radiother (Berl). 1989;30(5):459-63.
Changes of cytogenetic effectiveness of the therapeutic ray of fast neutrons were studied in water phantom in the Medical-Biological Complex of CyclotronU-120 at the Institute for Nuclear Research of the Academy of Sciences of the Ukrainian SSR. Investigations were done in a culture of lymphocytes of the peripheral human blood by means of metaphase method to find out chromosomal aberrations. The neutrons were generated by firing a thick beryllium target with a 13.6 MeV-deuteron ray in the nuclear reaction 9Be (d,n) 10B. The investigated dose range was 25-220 cGy. The results of the studies demonstrate that the cytogenetic effectiveness of radiation is reduced with increasing depth of the water phantom. The maximum reduction of the effect was seen in a depth up to 6 cm, which is attached to absorption of low-energetic neutron fraction. The obtained results confirm necessity of to filter the therapeutically applicable beam of neutron radiation.
在乌克兰苏维埃社会主义共和国科学院核研究所的回旋加速器U - 120的医学生物综合体的水模体中，研究了快中子治疗射线的细胞遗传学有效性变化。通过中期法对人外周血淋巴细胞培养物进行研究，以找出染色体畸变。中子是通过在核反应9Be(d,n)10B中用13.6 MeV的氘核射线轰击厚铍靶产生的。研究的剂量范围是25 - 220 cGy。研究结果表明，随着水模体深度的增加，辐射的细胞遗传学有效性降低。在深度达6 cm处观察到效应的最大降低，这与低能中子部分的吸收有关。所得结果证实了对治疗适用的中子辐射束进行过滤的必要性。
