El-Matary Wael, Dupuis Karine, Sokoro AbdulRazaq
Section of Paediatric Gastroenterology, Departments of Paediatrics, Faculty of Medicine, University of Manitoba, Winnipeg, MB, Canada.
The Children's Hospital Research Institute of Manitoba, University of Manitoba, Winnipeg, MB, Canada.
Acta Paediatr. 2015 Aug;104(8):827-30. doi: 10.1111/apa.13026. Epub 2015 May 8.
The role of noninvasive biologic markers for disease activity is very important in children with Crohn's disease. The aim of this study was to assess an association between disease activity and quantitative serum anti-Saccharomyces cerevisiae antibody (ASCA) titres.
Anti-Saccharomyces cerevisiae antibody immunoglobulin (Ig) A and immunoglobulin G titres, paediatric Crohn's disease activity index (PCDAI), serum albumin and C-reactive protein (CRP) were repeatedly measured simultaneously in children with Crohn's disease. A possible association between ASCA IgA and IgG titres and changes in PCDAI was examined.
Serial 136 measurements of ASCA IgA and IgG titres were documented in 57 children with Crohn's disease over a mean duration of 3.1 ± 2.1 years. In a univariate linear regression model, there were significant correlations between ASCA IgA titres and PCDAI (p < 0.001), CRP (p <0.01) and low serum albumin (p < 0.001), respectively. Similarly, ASCA IgG titres significantly correlated with PCDAI, CRP and low serum albumin.
Both ASCA IgA and IgG titres seemed to correlate well with clinical Crohn's disease activity in children. Measuring these antibodies may be considered during routine clinical care for those patients.
非侵入性生物标志物在克罗恩病患儿疾病活动中的作用非常重要。本研究旨在评估疾病活动与血清抗酿酒酵母抗体（ASCA）定量滴度之间的关联。
对克罗恩病患儿同时反复测量抗酿酒酵母抗体免疫球蛋白（Ig）A和免疫球蛋白G滴度、儿童克罗恩病活动指数（PCDAI）、血清白蛋白和C反应蛋白（CRP）。检测ASCA IgA和IgG滴度与PCDAI变化之间可能存在的关联。
对57例克罗恩病患儿进行了为期3.1±2.1年的ASCA IgA和IgG滴度系列测量，共136次。在单变量线性回归模型中，ASCA IgA滴度分别与PCDAI（p<0.001）、CRP（p<0.01）和低血清白蛋白（p<0.001）之间存在显著相关性。同样，ASCA IgG滴度与PCDAI、CRP和低血清白蛋白也显著相关。
ASCA IgA和IgG滴度似乎都与儿童克罗恩病的临床活动密切相关。对于这些患者，在常规临床护理过程中可考虑检测这些抗体。
