既往有妊娠期糖尿病的女性β细胞功能障碍与内脏脂肪组织分布有关。
β-cell dysfunction in women with previous gestational diabetes is associated with visceral adipose tissue distribution.
作者信息
Lekva Tove, Bollerslev Jens, Godang Kristin, Roland Marie Cecilie Paasche, Friis Camilla Margrethe, Voldner Nanna, Henriksen Tore, Ueland Thor
机构信息
Research Institute for Internal MedicineOslo University Hospital, Rikshospitalet, University of Oslo, P.b 4950 Nydalen, 0424 Oslo, NorwaySection of Specialized EndocrinologyDepartment of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, NorwayFaculty of MedicineUniversity of Oslo, Oslo, NorwayDepartment of ObstetricsOslo University Hospital, Rikshospitalet, Oslo, Norway
Research Institute for Internal MedicineOslo University Hospital, Rikshospitalet, University of Oslo, P.b 4950 Nydalen, 0424 Oslo, NorwaySection of Specialized EndocrinologyDepartment of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, NorwayFaculty of MedicineUniversity of Oslo, Oslo, NorwayDepartment of ObstetricsOslo University Hospital, Rikshospitalet, Oslo, Norway Research Institute for Internal MedicineOslo University Hospital, Rikshospitalet, University of Oslo, P.b 4950 Nydalen, 0424 Oslo, NorwaySection of Specialized EndocrinologyDepartment of Endocrinology, Oslo University Hospital, Rikshospitalet, Oslo, NorwayFaculty of MedicineUniversity of Oslo, Oslo, NorwayDepartment of ObstetricsOslo University Hospital, Rikshospitalet, Oslo, Norway.
出版信息
Eur J Endocrinol. 2015 Jul;173(1):63-70. doi: 10.1530/EJE-15-0153. Epub 2015 Apr 15.
CONTEXT
Glucose intolerance in pregnancy predicts an increased risk of future type 2 diabetes.
OBJECTIVE
The aim of the study was to evaluate glucose metabolism in women with and without gestational diabetes mellitus (GDM) at 5 years follow-up and identify risk factors associated with disturbed glucose metabolism post-partum.
DESIGN
This follow-up study included 300 consecutively enrolled women from a previous population-based cohort study. The participants underwent oral glucose tolerance test under pregnancy and in the follow-up study, in addition to dual-energy X-ray absorptiometry in the follow-up study.
RESULTS
Fifty-two women (17.7%) were found to have GDM in pregnancy with an odds ratio of 4.8 developing prediabetes 5 years later. β-cell function, but not insulin resistance or sensitivity, was reduced in the follow-up study after adjusting for known risk factors. Furthermore, visceral fat content at follow-up was increased in GDM women compared to non-GDM women, and the β-cell function declined with increasing visceral fat in both groups but was more pronounced in the women with previous GDM.
CONCLUSIONS
Women with GDM are at increased risk of developing prediabetes and have a decreased β-cell function 5 years post-partum that is associated with increased visceral fat mass.
背景
妊娠期间的糖耐量异常预示着未来患2型糖尿病的风险增加。
目的
本研究的目的是在5年随访期评估患有和未患有妊娠期糖尿病（GDM）的女性的糖代谢情况，并确定与产后糖代谢紊乱相关的危险因素。
设计
这项随访研究纳入了先前一项基于人群的队列研究中连续招募的300名女性。参与者在孕期及随访研究中接受了口服葡萄糖耐量试验，随访研究中还进行了双能X线吸收测定法检查。
结果
发现52名女性（17.7%）在孕期患有GDM，5年后发展为糖尿病前期的比值比为4.8。在对已知危险因素进行校正后，随访研究中β细胞功能降低，但胰岛素抵抗或敏感性未降低。此外，与非GDM女性相比，GDM女性随访时的内脏脂肪含量增加，两组中β细胞功能均随内脏脂肪增加而下降，但在既往有GDM的女性中更明显。
结论
GDM女性发生糖尿病前期的风险增加，产后5年β细胞功能下降，且与内脏脂肪量增加有关。
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