生物配体镍配合物的评估——对分布概况的影响
Evaluation of nickel complexes of bioligands-effect on distribution profile.
作者信息
Srivastava R C, Srivastava S K, Gupta S, Athar M, Hasan S K
机构信息
Toxicokinetic Division, Industrial Toxicology Research Centre, Lucknow, India.
出版信息
Res Commun Chem Pathol Pharmacol. 1989 Aug;65(2):253-6.
Distribution of various nickel-63 bioligand complexes in tissues of rats and their binding to subcellular fractions have been studied. Nickel-binding with glutathione and histidine significantly decreased nickel-63 accumulation while nickel-serum binding increased nickel body burden and its accumulation is subcellular fractions. Nickel-renal cytosol binding exhibited distribution pattern similar to serum complex only in lung tissue.
研究了各种镍-63生物配体复合物在大鼠组织中的分布及其与亚细胞组分的结合情况。镍与谷胱甘肽和组氨酸的结合显著降低了镍-63的积累，而镍与血清的结合增加了镍在体内的负荷及其在亚细胞组分中的积累。仅在肺组织中，镍与肾细胞质的结合呈现出与血清复合物相似的分布模式。
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