丁硫氨酸亚砜胺和双硫仑对环磷酰胺诱导的小鼠尿路毒性的影响
Modification of cyclophosphamide-induced urotoxicity by buthionine sulfoximine and disulfiram in mice.
作者信息
Ishikawa M, Takayanagi Y, Sasaki K
机构信息
Department of Pharmacology and Toxicology, Tohoku College of Pharmacy, Sendai, Japan.
出版信息
Res Commun Chem Pathol Pharmacol. 1989 Aug;65(2):265-8.
PMID:2587846
Abstract
The effect of buthionine sulfoximine (BSO) and disulfiram (DSF) on the urotoxicity induced by cyclophosphamide (CPA) was examined in mice. Pretreatment of mice with BSO (500 mg/kg, i.p.) 5 hr prior to CPA resulted in enhanced urotoxicity of CPA. In contrast, simultaneous administration of DSF (200 mg/kg, p.o.) decreased the urotoxicity of CPA.
摘要
在小鼠中研究了丁硫氨酸亚砜胺（BSO）和双硫仑（DSF）对环磷酰胺（CPA）诱导的尿路毒性的影响。在CPA给药前5小时用BSO（500mg/kg，腹腔注射）预处理小鼠，导致CPA的尿路毒性增强。相反，同时给予DSF（200mg/kg，口服）可降低CPA的尿路毒性。
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