信德省萨尔帕克地区素食者的血清同型半胱氨酸水平。

Serum homocysteine level in vegetarians in District Tharparker, Sindh.

作者信息

Kapoor Aneel, Zuberi Nudrat Anwar, Rathore M Imran, Baig Mukhtiar

机构信息

Aneel Kapoor, MPhil, Assistant Professor, Department of Biochemistry, Muhammad Medical College, Mirpurkhas, Sind, Pakistan.

Nudrat Anwar Zuberi, PhD, Professor & Head of Biochemistry Department, BMSI, JPMC, Karachi, Pakistan.

出版信息

Pak J Med Sci. 2015 Jan-Feb;31(1):127-30. doi: 10.12669/pjms.311.6111.

DOI:10.12669/pjms.311.6111

PMID:25878628

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4386171/

Abstract

OBJECTIVES

The aim of present study was to investigate serum homocysteine levels in apparently healthy vegetarians and ominvores in Mithi, district Tharparker, Sindh, Pakistan.

METHODS

This study was conducted in the Department of Biochemistry, Basic Medical Sciences Institute (BMSI), Jinnah Postgraduate Medical Center (JPMC), Karachi and blood samples were collected from Mithi, district Tharparker, Sindh, Pakistan, in 2012. One hundred vegetarian and one hundred omnivores (age ranging from 20-40 years) were enrolled for this study. Serum homocysteine levels were measured by the chemiluminescence enzyme immunoassay method.

RESULTS

Serum homocysteine (Hcy) level was considerably higher (p<0.001) in vegetarian group compared to omnivores. We further grouped and analyzed our study subjects according to their gender and according to Hcy level (greater than or lower than 15µmol/L). A considerable number of vegetarian subjects 30% were having Hcy >15µmol/L compared to omnivores 6%, (p<0.001). Gender-wise comparison showed that 27.02% male and 38.46% females had >15µmol/L serum Hcy level in vegetarian group and 6.9% male and 3.5% females had >15µmol/L serum Hcy level in omnivores group, but the difference was not significant in any group.

CONCLUSION

Vegetarians are more prone to develop hyperhomocysteinemia, so they are at high risk to develop cardiovascular disease.

摘要

目的

本研究旨在调查巴基斯坦信德省塔尔帕克地区米蒂市表面健康的素食者和杂食者的血清同型半胱氨酸水平。

方法

本研究于2012年在卡拉奇真纳研究生医学中心基础医学科学研究所（BMSI）生物化学系进行，血液样本采集自巴基斯坦信德省塔尔帕克地区米蒂市。本研究招募了100名素食者和100名杂食者（年龄在20 - 40岁之间）。采用化学发光酶免疫分析法测定血清同型半胱氨酸水平。

结果

与杂食者相比，素食组血清同型半胱氨酸（Hcy）水平显著更高（p<0.001）。我们进一步根据研究对象的性别以及Hcy水平（高于或低于15µmol/L）进行分组和分析。与杂食者的6%相比，相当数量（30%）的素食者Hcy>15µmol/L（p<0.001）。按性别比较显示，素食组中27.02%的男性和38.46%的女性血清Hcy水平>15µmol/L，杂食组中6.9%的男性和3.5%的女性血清Hcy水平>15µmol/L，但两组差异均无统计学意义。