Li Xiang-Sheng, Yang Wei-Long, Shen Fa-Zheng, Gao Guo-Jun, Ma Ji-Wei, Jin Bao-Zhe
Xiang-Sheng Li, Department of Neurosurgery, The First Affiliated Hospital of Xinxiang Medical University, Weihui 453100, PR China.
Wei-Long Yang, Department of Neurosurgery, The Third Affiliated Hospital of Xinxiang Medical University, Xinxiang 453003, PR China.
Pak J Med Sci. 2015 Jan-Feb;31(1):178-82. doi: 10.12669/pjms.311.6440.
To evaluate the short-term therapeutic effects of low-dose cytarabine plus surgical resection on elderly patients with trigeminal nerve tumor and to observe the safety.
A total of 120 elderly patients with trigeminal nerve tumor were divided into a treatment group and a control group by random draw (n=60), and both groups were subjected to resection by stereotactic image-guided endoscopic nasal surgery. Afterwards, the control group was administered with high-dose cytarabine while the treatment group was given low-dose cytarabine for 14 days.
Both groups completed treatment, but the effective rate of the treatment group (96.7%) was significantly higher than that of the control group (83.3%) (P < 0.05). The pain scores of the two groups were similar at T0, T1 and T2, but the score of the treatment group at T2 was significantly different from those at T0 and T1 (P < 0.05). During treatment, the treatment group was significantly less prone to complications such as headache, vomiting, vision impairment, nausea and local swelling than the control group (P < 0.05). During three months of follow-up, the appetite, sleep and daily living scores were significantly higher than those of the control group (P < 0.05).
Stereotactic image-guided surgery was able to treat trigeminal nerve tumor well, and the effect was enhanced by low-dose cytarabine that improved postoperative outcomes and quality of life by dramatically decreasing complications.
评估小剂量阿糖胞苷联合手术切除对老年三叉神经肿瘤患者的短期治疗效果，并观察其安全性。
将120例老年三叉神经肿瘤患者通过随机抽签分为治疗组和对照组（n = 60），两组均接受立体定向影像引导下的鼻内镜手术切除。术后，对照组给予大剂量阿糖胞苷，治疗组给予小剂量阿糖胞苷，持续14天。
两组均完成治疗，但治疗组的有效率（96.7%）显著高于对照组（83.3%）（P < 0.05）。两组在T0、T1和T2时的疼痛评分相似，但治疗组在T2时的评分与T0和T1时显著不同（P < 0.05）。治疗期间，治疗组比对照组更不易出现头痛、呕吐、视力损害、恶心和局部肿胀等并发症（P < 0.05）。在三个月的随访期间，治疗组的食欲、睡眠和日常生活评分显著高于对照组（P < 0.05）。
立体定向影像引导手术能够很好地治疗三叉神经肿瘤，小剂量阿糖胞苷可增强疗效，通过显著减少并发症改善术后结局和生活质量。
