Bhardwaj Rajni M, Raval Vishal, Oswald Iain D H, Florence Alastair J
Strathclyde Institute of Pharmacy and Biomedical Sciences, University of Strathclyde, 161 Cathedral Street, Glasgow G4 0RE, Scotland.
Acta Crystallogr E Crystallogr Commun. 2015 Jan 10;71(Pt 2):139-41. doi: 10.1107/S2056989014028096. eCollection 2015 Feb 1.
The mixed solvated salt 4-(2-chloro-dibenzo[b,f][1,4]oxazepin-11-yl)piperazin-1-ium acetate-acetic acid-cyclo-hexane (2/2/1), C17H17ClN3O(+)·C2H3O2 (-)·C2H4O2·0.5C6H12, crystallizes with one mol-ecule of protonated amoxapine (AXPN), an acetate anion and a mol-ecule of acetic acid together with half a mol-ecule of cyclo-hexane. In the centrosymmetric crystal, both enanti-omers of the protonated AXPN mol-ecule stack alternatively along [001]. Acetate anions connect the AXPN cations through N-H⋯O hydrogen bonding in the [010] direction, creating a sheet lying parallel to (100). The acetic acid mol-ecules are linked to the acetate anions via O-H⋯O hydrogen bonds within the sheets. Within the sheets there are also a number of C-H⋯O hydrogen bonds present. The cyclo-hexane solvent mol-ecules occupy the space between the sheets.
混合溶剂化盐4-(2-氯-二苯并[b,f][1,4]恶唑并[11]哌嗪-1-鎓)乙酸盐-乙酸-环己烷(2/2/1)，即C17H17ClN3O(+)·C2H3O2 (-)·C2H4O2·0.5C6H12，由一分子质子化阿莫沙平（AXPN）、一个乙酸根阴离子、一分子乙酸以及半分子环己烷结晶而成。在中心对称晶体中，质子化AXPN分子的两种对映体沿[001]交替堆积。乙酸根阴离子通过N-H⋯O氢键在[010]方向连接AXPN阳离子，形成一个平行于(100)的平面。乙酸分子通过平面内的O-H⋯O氢键与乙酸根阴离子相连。平面内还存在许多C-H⋯O氢键。环己烷溶剂分子占据平面之间的空间。
