ANTHONY NOLAN RESEARCH INSTITUTE; UNIVERSITY COLLEGE LONDON.
Blood. 2015 Apr 16;125(16):2456-7. doi: 10.1182/blood-2015-03-630780.
In this issue of Blood, Nguyen et al show that mycophenolic acid (MPA) induces GTP depletion, which inhibits the function of transcription initiation factor I (TIF-IA) and impacts the interaction of TIF-IA with ErbB3-binding protein 1 (Ebp1), a key in regulating proliferating cell nuclear antigen (PCNA) expression and ribosomal RNA (rRNA) synthesis in T cells during activation.
在本期《Blood》中，Nguyen 等人表明麦考酚酸（MPA）可诱导 GTP 耗竭，从而抑制转录起始因子 I（TIF-IA）的功能，并影响 TIF-IA 与 ErbB3 结合蛋白 1（Ebp1）的相互作用，Ebp1 是调节 T 细胞激活过程中增殖细胞核抗原（PCNA）表达和核糖体 RNA（rRNA）合成的关键蛋白。
