Frangopoulou E, Linos A, Mentzelopoulou P, Papaefthimiou M, Efstratiadou M
Department of Diagnostic Cytology, Alexandra Hospital, Athens, Greece.
Acta Cytol. 1989 Nov-Dec;33(6):839-42.
The secular trends in the detection rates for cervical intraepithelial neoplasia (CIN) and invasive carcinoma were evaluated for a population lacking a mass screening program. For the period from 1980 through 1987, 185,659 Papanicolaou smears from 176,511 women were examined. The average annual age-adjusted detection rate for invasive cervical cancer declined from 3.7 x 10(-3) in 1980 to 1.4 x 10(-3) in 1987. The rate of cytologic findings consistent with CIN 3 and verified by histology increased from 0.7 x 10(-3) to 2.6 x 10(-3), and the rate of findings consistent with CIN 1 and CIN 2 increased from 4.3 x 10(-3) to 7.2 x 10(-3). The yield of Papanicolaou smear diagnoses consistent with CIN 3 was substantial (more than one case per 1,000) for women up to 60 years old, but was insignificant for older women.
对一个缺乏大规模筛查项目的人群，评估了宫颈上皮内瘤变（CIN）和浸润癌的检出率的长期趋势。在1980年至1987年期间，检查了来自176,511名女性的185,659份巴氏涂片。宫颈浸润癌的年龄调整后年均检出率从1980年的3.7×10⁻³降至1987年的1.4×10⁻³。经组织学证实与CIN 3一致的细胞学检查结果的比率从0.7×10⁻³增至2.6×10⁻³，与CIN 1和CIN 2一致的检查结果的比率从4.3×10⁻³增至7.2×10⁻³。对于60岁及以下的女性，与CIN 3一致的巴氏涂片诊断的检出率相当可观（每1000人中有超过1例），但对于老年女性则不显著。
