生长抑素受体亚型SSTR - 2、SSTR - 3和SSTR - 5的mRNA表达及其在胰腺癌中的意义。
mRNA expression of somatostatin receptor subtypes SSTR-2, SSTR-3, and SSTR-5 and its significance in pancreatic cancer.
作者信息
Shahbaz Muhammad, Ruliang Fang, Xu Zhang, Benjia Liang, Cong Wang, Zhaobin He, Jun Niu
机构信息
Department of Hepatobiliary Surgery, Qilu Hospital, Shandong University, Wenhua west Road #44, Jinan, 250012, China.
Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Public Health, Jinan, 250012, Shandong, People's Republic of China.
出版信息
World J Surg Oncol. 2015 Feb 13;13:46. doi: 10.1186/s12957-015-0467-z.
BACKGROUND
The aim of this study is to investigate the expressions of somatostatin receptor (SSTR), SSTR-2, SSTR-3, and SSTR-5, in pancreatic tissue and non-cancerous tissue and elucidate their clinical significance.
METHODS
The expression of somatostatin receptor subtypes SSTR-2, SSTR-3, and SSTR-5 messenger RNA (mRNA) in 108 cases of cancer tissue and adjacent tissue in patients with pancreatic cancer was detected by reverse transcriptase polymerase chain reaction (RT-PCR). Expression of SSTR-2, SSTR-3, and SSTR-5 mRNA was evaluated after specimens were taken from selected patients who underwent surgical resection by Whipple's operation. We speculated the clinical significance of the expression of somatostatin receptor (SSTR) subtype genes SSTR-2, SSTR-3, and SSTR-5 in pancreatic tissue and non-cancerous tissue and further elucidated their clinical significance.
RESULTS
The expression rates of SSTR-2 mRNA in cancer and adjacent tissue of 108 patients with pancreatic cancer were 81.5% (88/108) and 97.2% (105/108), respectively; SSTR-3 mRNA expression rates were 69.4% (75/108) and 55.6% (60/108). SSTR-5 mRNA expression rates were 13.0% (14/108) and 18.5% (20/108).
CONCLUSION
We propose that SSTR-2 plays an important role in clinical implications for patients with pancreatic cancer undergoing somatostatin or its analog therapy.
背景
本研究旨在调查胰腺癌组织和癌旁组织中生长抑素受体（SSTR）、SSTR-2、SSTR-3和SSTR-5的表达情况，并阐明其临床意义。
方法
采用逆转录聚合酶链反应（RT-PCR）检测108例胰腺癌患者癌组织及癌旁组织中生长抑素受体亚型SSTR-2、SSTR-3和SSTR-5信使核糖核酸（mRNA）的表达。从接受惠普尔手术的选定患者中获取标本后，评估SSTR-2、SSTR-3和SSTR-5 mRNA的表达。我们推测生长抑素受体（SSTR）亚型基因SSTR-2、SSTR-3和SSTR-5在胰腺癌组织和癌旁组织中的表达的临床意义，并进一步阐明其临床意义。
结果
108例胰腺癌患者癌组织和癌旁组织中SSTR-2 mRNA的表达率分别为81.5%（88/108）和97.2%（105/108）；SSTR-3 mRNA表达率分别为69.4%（75/108）和55.6%（60/108）。SSTR-5 mRNA表达率分别为13.0%（14/108）和18.5%（20/108）。
结论
我们认为SSTR-2在接受生长抑素或其类似物治疗的胰腺癌患者的临床意义中起重要作用。
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