Neu D, Mairesse O, Newell J, Verbanck P, Peigneux P, Deliens G
Brugmann University Hospital, U.L.B./V.U.B, Sleep Laboratory & Unit for Chronobiology U78, Arthur Van Gehuchten Square, Building Hh, 1020 Brussels, Belgium; UNI, ULB Neurosciences Institute, Faculty of Medicine, Laboratory for Medical Psychology ULB312, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium; Center for the Study of Sleep Disorders, Edith Cavell Medical Institute, CHIREC, Brussels, Belgium.
Brugmann University Hospital, U.L.B./V.U.B, Sleep Laboratory & Unit for Chronobiology U78, Arthur Van Gehuchten Square, Building Hh, 1020 Brussels, Belgium; UNI, ULB Neurosciences Institute, Faculty of Medicine, Laboratory for Medical Psychology ULB312, Université Libre de Bruxelles (U.L.B.), Brussels, Belgium; Department of Experimental and Applied Psychology (EXTO), Vrije Universiteit Brussel (V.U.B.), Brussels, Belgium; Royal Military Academy (R.M.A.), Department LIFE, Brussels, Belgium.
Neurophysiol Clin. 2015 May;45(2):167-75. doi: 10.1016/j.neucli.2014.10.004. Epub 2015 Apr 15.
We investigated effects of NREM and REM predominant sleep periods on sleepiness and psychomotor performances measured with visual analog scales and the psychomotor vigilance task, respectively. After one week of stable sleep-wake rhythms, 18 healthy sleepers slept 3hours of early sleep and 3hours of late sleep, under polysomnographic control, spaced by two hours of sustained wakefulness between sleep periods in a within subjects split-night, sleep interruption protocol. Power spectra analysis was applied for sleep EEG recordings and sleep phase-relative power proportions were computed for six different frequency bands (delta, theta, alpha, sigma, beta and gamma). Both sleep periods presented with similar sleep duration and efficiency. As expected, phasic NREM and REM predominances were obtained for early and late sleep conditions, respectively. Albeit revealing additive effects of total sleep duration, our results showed a systematic discrepancy between psychomotor performances and sleepiness levels. In addition, sleepiness remained stable throughout sustained wakefulness during both conditions, whereas psychomotor performances even decreased after the second sleep period. Disregarding exchanges for frequency bands in NREM or stability in REM, correlations between outcome measures and EEG power proportions further evidenced directional divergence with respect to sleepiness and psychomotor performances, respectively. Showing that the functional correlation pattern changed with respect to early and late sleep condition, the relationships between EEG power and subjective or behavioral outcomes might however essentially be related to total sleep duration rather than to the phasic predominance of REM or NREM sleep.
我们分别通过视觉模拟量表和精神运动警觉任务，研究了以非快速眼动（NREM）为主和以快速眼动（REM）为主的睡眠阶段对嗜睡和精神运动表现的影响。在一周稳定的睡眠-觉醒节律之后，18名健康睡眠者在多导睡眠图监测下，进行了一次受试者内分夜睡眠中断实验，早期睡眠3小时，晚期睡眠3小时，两个睡眠阶段之间间隔2小时持续清醒。对睡眠脑电图记录进行功率谱分析，并计算六个不同频段（δ、θ、α、σ、β和γ）的睡眠阶段相对功率比例。两个睡眠阶段的睡眠时间和效率相似。正如预期的那样，早期和晚期睡眠条件下分别出现了以阶段性NREM和REM为主的情况。尽管揭示了总睡眠时间的累加效应，但我们的结果显示精神运动表现和嗜睡水平之间存在系统性差异。此外，在两种情况下，整个持续清醒期间嗜睡程度保持稳定，而精神运动表现在第二个睡眠阶段后甚至有所下降。无论NREM频段的交换情况或REM的稳定性如何，结果测量与脑电图功率比例之间的相关性进一步证明了在嗜睡和精神运动表现方面的方向差异。结果表明，脑电图功率与主观或行为结果之间的关系可能主要与总睡眠时间有关，而不是与REM或NREM睡眠的阶段性优势有关，这表明功能相关模式因早期和晚期睡眠条件而改变。
