微波辅助纳米金刚石与紫杉醇的高效共轭

Microwave-assisted efficient conjugation of nanodiamond and paclitaxel.

作者信息

Hsieh Yi-Han, Liu Kuang-Kai, Sulake Rohidas S, Chao Jui-I, Chen Chinpiao

机构信息

Department of Chemistry, National Dong Hwa University, Soufeng, Hualien 974, Taiwan.

Department of Biological Science and Technology, National Chiao Tung University, Hsinchu 30068, Taiwan.

出版信息

Bioorg Med Chem Lett. 2015;25(10):2074-7. doi: 10.1016/j.bmcl.2015.03.089. Epub 2015 Apr 4.

DOI:10.1016/j.bmcl.2015.03.089

PMID:25890802

Abstract

Nanodiamond has recently received considerable attention due to the various possible applications in medical field such as drug delivery and bio-labeling. For this purpose suitable and effective surface functionalization of the diamond material are required. A versatile and reproducible surface modification method of nanoscale diamond is essential for functionalization. We introduce the input of microwave energy to assist the functionalization of nanodiamond surface. The feasibility of such a process is illustrated by comparing the biological assay of ND-paclitaxel synthesized by conventional and microwave irradiating. Using a microwave we manage to have approximately doubled grafted molecules per nanoparticle of nanodiamond.

摘要

由于纳米金刚石在药物递送和生物标记等医学领域的各种潜在应用，其最近受到了广泛关注。为此，需要对金刚石材料进行合适且有效的表面功能化处理。一种通用且可重复的纳米级金刚石表面改性方法对于功能化至关重要。我们引入微波能量输入以辅助纳米金刚石表面的功能化。通过比较常规合成和微波辐照合成的纳米金刚石-紫杉醇的生物学测定，说明了该过程的可行性。使用微波，我们设法使每颗纳米金刚石纳米颗粒上接枝的分子数量增加了约一倍。